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Articles by A.J. Uraku
Total Records ( 4 ) for A.J. Uraku
  A.J. Uraku , N. Ezeani , C. Ezeali , F.U. Ali , C.A. Afiukwa and L.N. Ebenyi
  Effects of leaf extract of Spilanthes uliginosa (SW) on total protein, albumin, total and conjugated bilirubin levels in ethylene glycol exposed albino rats were studied. The animals were divided into 3 groups namely; A, B and C and groups A and B were subdivided into 2; AI, A2, B1 and B2. All the groups and subgroups contained 6 albino rats each and were given water and food ad libitum. Groups A1 and B1 with A2 and B2 were treated with 1.85 mg kg–1 and 3.70 mg kg–1 of 90% ethylene glycol intraperitoneally once, respectively. Groups B1 and B2 were also given 1 mL of the plant extract, respectively by oral incubation for 21 consecutive days while group C received only the water and food. The average body weights of the treated groups decreased significantly at p<0.05 compared to control. The result showed no significant change at p<0.05 in total protein levels and significant decrease in albumin, total and direct bilirubin levels compare to control. The result obtained suggests toxicity of ethylene glycol and the ability of the plant extract to affect the levels of the analyzed parameters.
  P.M. Aja , A.N.C. Okaka , U.A. Ibiam , A.J. Uraku and P.N. Onu
  The proximate analysis of Talinum triangulare was carried out in both wet and dry conditions respectively. The results revealed the presence of carbohydrates (10.87±3.99 mg/g and 12.38±2.76 mg/g), steroids (106.61±2.53 mg/100mg and 11.37±1.19 mg/100g), protein (3.52±0.32% and 18.75±2.72%), oil content (3.52% and 1.44%), b-Carotene (114.5±1.49 mg/g and 40.02±0.50 mg/g) and crude fibre (12.00% and 8.50%) in dry and wet samples respectively. The wet sample was assayed for pectinases at various temperatures. This revealed the presence of pectinases with specific activities of 38.64 units/kg protein, 55.44 units/kg protein, 61.14 units/kg protein and 62.09 units/kg protein at 35, 55, 75 and 95oC respectively. These results indicate that the leaves contain an appreciable amount of nutrients and should be included in our meal for a balanced diet. The high amount of pectinases detected lends credence to the traditional use of water leaf as a softener of other vegetables species and a possible industrial application.
  A.J. Uraku
  Plant as a source of herbal medicine is the oldest form of medicine known to mankind. It was the mainstay of many earlier civilization and still the most widely practiced form of medicine in the world currently. The GS-MS analysis of the leaf extract of Spilanthes uliginosa (Sw) was investigated. The analysis revealed the presence of six peaks from the chromatogram which showed six phytocompounds. The major phytocompounds identified in the leaf extract are hexadecanoic acid (8.68%), hepta-9, 10, 11-trienoic acid (19.36%), octadecenoic acid (8.14%), 5- hydroxylmethyl heptadecane (14.02%), docosane aldehyde (41.72%) and 1-ethoxyoctadecane (8.08%). The presence of these assorted chemicals may be responsible for the beneficial potentials of Spilanthes uliginosa (Sw) in tradomedicine.
  A.J. Uraku , O.H. Uraku , S.C. Onuoha , N. Edwin , C. Ezeali , N.N. Ezeani , O.U. Obasi , N.V. Ogoh , E.J. Dingwoke , O.F. Orinya , F.N. Nweke , P.E. Ozioma and B.N. Enemchukwu
  Background and Objective: Lead is an environmental pollutant. The painful invasive chelation therapy makes it exigent to continue the protracted treatment against lead toxicity. This study is aimed at evaluating the protective effect of the methanol and flavonoid-rich leaf extracts of T. triangulae on lead-induced toxicity. Materials and Methods: Thirtysix male albino rats were used and were distributed into five groups; A, B, C D and E. Groups D and E were further subdivided into three; D1, D2, D3, E1, E2 and E3. Both groups and subgroups contained four rats each. All groups except A were intraperitoneally injected a single dose of 50 mg kg1 b.wt., of lead chloride and commenced treatment within 30 min of lead injection. Group A and B were given distilled water and 50 mg kg1 b.wt., of lead chloride only, respectively. Group C was treated only with 40 mg kg1 vitamin C while groups D1, D2, D3 and E1, E2, E3 were treated with 50, 100 and 200 mg kg1 b.wt., of methanol and flavonoid-rich leaf extract of T. triangulae, respectively for 14 days once daily. Blood were collected for determination of antioxidant indices in plasma using standard method and data were analyzed using SPSS version 20. Results: The result showed that methanol and flavonoid-rich extracts significantly (p<0.05) decrease the Malondialdehyde (MDA) level that was triggered by the increase oxidative stress when treated with lead. The levels of glutathione and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were increased significantly when treated with the extracts. Conclusion: The outcome of this study showed that the extracts have a protective effect on lead-induced toxicity.
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