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Articles by A.I. Oreagba
Total Records ( 3 ) for A.I. Oreagba
  A.I. Oreagba , O.O. Aina , O. Awodele , S.O. Olayemi , A.F.B. Mabadeje and R.B. Ashorobi
  Grapefruit juice was assessed for chemoprophylactic activity against Chloroquine-sensitive Plasmodium berghei berghei infection in mice. A standard inoculum of 1x106 infected erythrocytes was used to assess the prophylactic effect of grapefruit juice (15 mL kg-1) and this was compared with the prophylactic effect of high dose Ascorbic acid (150 mg mL-1 or 2.25 g kg-1). The result of the experiment showed that grapefruit juice and high dose vitamin C significantly delayed the establishment of parasitaemia compared with the control group. Furthermore, grapefruit juice and ascorbic acid prolonged the mean survival time of the mice with corresponding decreases in mean peak percentage parasitaemia, respectively. Grapefruit juice however demonstrated a stronger chemoprophylactic activity than ascorbic acid (p<0.05). These effects were however lower than the standard prophylactic drug (Pyrimethamine-1.2 mg kg-1). Regular intake of grape juice may protect against malaria infection. Further studies are necessary to elucidate possible mechanisms involved.
  S.O. Olayemi , A.P. Arikawe , A. Akinyede , A.I. Oreagba and O. Awodele
  Mice are considered a comparable genetic model to humans and it is well established that mice also exhibit natural differences in susceptibility to malarial infection. The study aimed to determine and compare the effects of artesunate, artesunate+amodiaquine combination, amodiaquine and quinine on biochemical parameters such as liver catalase, plasma glutathione peroxidase, lipid peroxidation, total plasma proteins and plasma pH in the course of a malaria infection. Thirty male albino mice of eight weeks were randomly divided into 6 groups based on the specific antimalarial drug administered and two groups served as control and parasitized untreated groups respectively. The parasite used was a chloroquine-sensitive strain of Plasmodium berghei NK 65, inoculated into mice and observed for twelve days, followed by four days of antimalarial drug administration. Plasma sample was obtained and assay was done for lipid peroxidation, glucose concentration, plasma pH and liver catalase. Plasma pH was significantly lower (p<0.05) in the antimalarial groups compared to the Control and Parasitized untreated groups. Plasma glucose was significantly lower (p<0.05) in the parasitized untreated and antimalarial compared to the control group. Liver catalase was significantly higher (p<0.05) in the Parasitized untreated and antimalarial groups compared to the control group. Lipid peroxidation revealed different results within the antimalarial groups. Artemisinin and its combination with amodiaquine resulted in lowered plasma glucose and greater degree of lipid peroxidation, hence an index of suspicion should be put on possibility of hypoglycaemia with the use of ACTs.
  A.I. Oreagba and R.B. Ashorobi
  The present study was conducted to evaluate the antiplasmodial activity of retinol on chloroquine-sensitive Plasmodium berghei berghei infection in mice. Albino mice weighing 18-25 g where treated with retinol (50-200 mg kg-1) in a set of experiments to investigate chemotherapeutic and prophylactic effect against Plasmodium berghei berghei infection in mice. Treatment in one of the chemotherapeutic groups continued throughout the study period. Retinol demonstrated a mild dose dependent schizontocidal effect on early and established infection. This effect became stronger on chronic administration but it also produced toxic manifestations and eventual death in most of the animals. Retinol also demonstrated a prophylactic effect by significantly delaying the onset of infection. The repository activity of retinol was however lower than that of the standard drug (Pyrimethamine-1.2 mg kg/day). Retinol possesses antiplasmodial activity especially during chronic administration thus suggesting that it might have a role in malaria control. Further studies in the area of its structural activity relationships are needed to justify this assertion.
 
 
 
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