Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by A.H. Yaro
Total Records ( 5 ) for A.H. Yaro
  A.M. Musa , A.H. Yaro , H. Usman , M.G. Magaji and M. Habu
  The phytochemical constituents and some neuropharmacological activity of the methanolic leaf extract of Cissus cornifolia (Bak.) Planch [Family: Vitaceae] was evaluated in mice employing various models. The preliminary qualitative phytochemical analysis carried out on the methanolic leaf extract of Cissus cornifolia revealed the presence of alkaloids, flavonoids, saponins, steroids/terpenoids, stilbenoids and tannins. The neuropharmacological effects of the methanolic leaf extract of Cissus cornifolia on CNS were evaluated using diazepam sleeping time, exploratory behaviour (head dip tests), motor coordination and acute toxicity studies in mice. The extract at tested doses (10, 20 40 mg kg-1 body weight i.p.) produced reduction in exploratory behaviour (head dip test), beam walking assay (foot slips) and potentiate the diazepam-induced sleep in mice; the LD50 was found to be 775.0 mg kg-1 body weight i.p. in mice. These results corroborates with the traditional usage of this plant as a remedy against mental derangement as confirmed by the sedative activity expressed by the extract.
  Y.M. Sani , A.M. Musa , A.H. Yaro , M.B. Sani , A. Amoley and M.G. Magaji
  Cissus polyantha is used in African traditional medicine is the management of pain and inflammatory conditions. This study was therefore designed to evaluate the analgesic and anti-inflammatory activities of the methanol extract of the leaf of Cissus polyantha, as well as to establish the class of phytochemical constituents present in the extract. The analgesic effect was studied using acetic acid-induced writhing and hot plate tests in mice, while anti-inflammatory effect was investigated using carrageenan-induced hind paw oedema in rats. The results of the study showed that the extract significantly (50, 100, 200 mg kg-1) (p<0.001) and dose-dependently inhibited acetic acid-induced writhing. The extract at dose of 100 mg kg-1 increased the mean pain responses by 69.25% compared to control. At the end of third hour after carrageenan administration, the various doses of the extract offered 65.67, 70.15 and 67.16% inhibition of hind paw oedema, respectively. These effects were more remarkable than those produced by ketoprofen (63.8%). Preliminary phytochemical screening revealed the presence of steroids, flavonoids, saponins, tannins and anthraquinones. The intraperitoneal mean lethal dose (LD50) of the extract in mice was estimated to be 774.6 mg kg-1. The findings of this study showed that the methanol leaf extract of Cissus polyantha contains some pharmacologically active principle(s) with analgesic and anti-inflammatory activities and lend credence of the ethnomedical use of the plant in the management of pain and inflammatory conditions.
  G. Ibrahim , S. Abdulmumin , K.Y. Musa and A.H. Yaro
  The anticonvulsant effects of the crude flavonoid fraction of the stem bark of Ficus sycomorus were studied using the subcutaneous Pentylenetetrazole (PTZ) and Maximal Electroshock Test (MEST) models in mice and chicks respectively. The crude flavonoid fraction exhibited a significant (p<0.05) latency in mean onset and mean time of death of convulsed animal with a 20% protection at a dose of 10 mg kg-1 body weight i.p. (comparable to Valproic acid at 200 mg kg-1) while it showed a significant (p<0.05) and dose dependent maximal protection (83.3%) in the Maximal Electroshock Test (MEST) at an optimal dose of 20 mg kg-1 body weight i.p. (comparable to Phenytoin at 20 mg kg-1). The results obtained supported the claim in the traditional use of the stem bark of the plant in the management of epilepsy.
  M.G. Magaji , Y. Yakubu , R.A. Magaji , A.M. Musa , A.H. Yaro and I.M. Hussaini
  Schizophrenia is a highly disabling chronic psychiatric illness. The existing antipsychotic agents are associated with untoward effects and drug interactions leading to the intensification of search for newer agents with better efficacy and safety profile. Securinega virosa is a commonly used medicinal plant in African traditional medicine. The decoction of the leaves of the plant in combination with other plants is used in the management of mental illness. In this study, we evaluate the antipsychotic potential of the methanol leaf extract (25, 50 and 100 mg kg-1) of the plant using apomorphine-induced stereotypic climbing behavior and swim-induced grooming tests, all in mice. The CNS depressant effect was also evaluated using ketamine-induced sleep test mice. The extract at the highest dose tested (100 mg kg-1) significantly reduced the apomorphine (1 mg kg-1)-induced stereotypic climbing behavior after 30 min. Similarly, haloperidol (2 mg kg-1), the standard agent significantly (p<0.001) decreased the mean climbing behavior. In the swim-induced grooming test, the extract significantly (p<0.01) and dose-dependently decreased the total grooming time. Similarly, haloperidol (2 mg kg-1) significantly (p<0.001) decreased the mean grooming activity. The extract significantly increased the total ketamine-induced sleep duration at doses of 50 and 100 mg kg-1. These findings suggest that the extract possesses antipsychotic and sedative potentials and lend credence to the ethnomedical use of the leaves of the plant in the management of mental illness.
  H. Usman , A.H. Yaro and M.M. Garba
  Analgesic and anti-inflammatory effects of the ethanolic flower extract of Newbouldia laevis were studied in rodents. Investigations were carried out on acetic acid-induced writhing in mice and carrageenan-induced hind paw oedema in rats. The results showed that the ethanol extract possessed significant (p< 0.001) anti-nociceptive activity between 50 and 200 mg kg-1 intraperitoneally (i.p.) in mice and also dose dependent anti-inflammatory activity between 50 and 200 mg kg-1 (i.p.) in rats. These effects were compared favourably with that expressed by ketoprofen (10 mg kg-1 i.p). From the results obtained, although relatively toxic the extract exhibited highest anti-nociceptive and anti-inflammatory activities at the dosage of 200 mg kg-1 (i.p.). These data corroborate with the traditional use of this plant in the treatment of rheumatic pain and other types of pain reported in traditional medicine.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility