Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by A.H. Doulah
Total Records ( 2 ) for A.H. Doulah
  F. Rahim , B. Keikhaei , A. Sarkaki and A.H. Doulah
  The present study was conducted in order to investigate the effects of right-unilateral lesion of substantia nigra neurons by means of Ibotenic acid, a cholinergic-selective neurotoxin, on hematological parameters in rats. Thirty male Wistar rats weighing 200±50 g at the start of the experiment were used. The substantia nigra was right-unilateral lesioned by stereotaxic microinjections of ibotonic acid. Seven days after neurosurgery, we assessed the total number of White Blood Cells (WBC), the total number of Red Blood Cells (RBC), Red Cell Distribution (RDW), platelet and hemoglobin level and the erythrocyte indexes (Mean Cell Volume, (MCV), Mean Cell Hemoglobin,(MCH), Mean Cell Hemoglobin Concentration (MCHC)). Ibotenic acid treatment induced a highly significantly decrease of white blood cells, followed by significant decrease in red blood cells and hemoglobin level comparative with sham-operated rats. Also in the ibotenic acid-lesioned rats the erythrocyte indexes (Mean Cell Volume, MCV; Mean Cell Hemoglobin, MCH were significantly decreased comparative with sham-operated rats. By contrast, platelets, mean cell hemoglobin concentration and red blood cell distribution width were significantly increased in the ibotonic-acid lesioned rat versus sham-operated animals. On the whole, the obtained data indicate the important role of the central nerves system in the regulation of erythrocyte dynamics.
  M. Malek , S. Zahedi Asl , A. Sarkaki , Y. Farbood and A.H. Doulah
  The aim of this study was to evaluate the effect of intra-hippocampal injection of Growth Hormone (GH) on impaired spatial cognition in rats with Alzheimer’s Disease (AD). Growth hormone replacement therapy leading to improved cognition and well-being has mainly been carried in GH-deficient patients. Neverthelss, relatively only a few studies have investigated the function of GH in the brain. Aged Wistar male rats (350-400 g, 18-20 months old) were randomly divided into 6 groups (7 in each): Control (healthy aged); L; L+Veh; L+GH10; L+GH20 and L+GH40. Rats with AD-like cognitive deficiency was induced by injection of ibotenic acid into Nucleus Basalis of Meynert (NBM) bilaterally (5 μg 0.5 μL-1, each side). A guide cannula was implanted in the right hippocampus under stereotaxic surgery for injection of human recombinant GH (10, 20 and 40 μg 2 μL-1, during 5 min, twice daily, 9:00 am and 3:00 pm, for 7 days). All rats were trained in Morris water maze to evaluate the spatial learning and memory. Escape latency, traveled distance to find hidden platform and percent time spent in gaol qudrant did not differ between L and L+Veh groups, while latency and distance were reduced significantly. But percent time spent in gaol quadrant (without hidden platform) was increased significantly in NBM-lesioned rats treated with GH (L+GH groups) dose dependently to compare with vehicle treated group. These results suggest that intra-hippocampal injection of GH to aged rats with dementia type of AD (with NBM lesioned) could improve spatial cognition.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility