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Articles by A.H. Adebayo
Total Records ( 3 ) for A.H. Adebayo
  R. Aliyu , A.H. Adebayo , D. Gatsing and I.H. Garba
  The effects of Commiphora africana ethanolic leaf extract on some biochemical markers of liver and kidney functions were investigated in rats. The results showed a significant (p<0.05) decrease in serum albumin after 10 days of treatment for the group administered 100 mg kg-1 body weight of the extract. There was no significant (p>0.05) change in alkaline phosphatase activity, while groups administered 100 and 150 mg kg-1 showed significant (p<0.05) increases in serum total bilirubin, after 10 days of treatment. Also, aspartate aminotransferase activity was significantly increased in groups administered 100 mg kg-1 (p<0.01) and 150 mg kg-1 (p<0.05), while alanine aminotransferase showed no significant (p>0.05) increase. The group administered 25 mg kg-1 showed significant (p<0.05) increase in serum creatinine after 24 h of treatment. The results of the liver and kidney histology showed that there was no noticeable damage to the liver tissues of rats administered the extract. However, hydropic degeneration of the cortical-tubular epithelium and glomerulus was seen with the group administered 100 mg kg-1. Similarly, the group treated with 150 mg kg-1 showed acute glomerulonephritis and proliferation of the mesangial cells. These results suggest that C. africana extract may enhance liver function at low doses and may cause adverse effects at high doses.
  O.A. Abolaji , A.H. Adebayo and O.S. Odesanmi
  The nutritional potentials of three medicinal plant parts used by pregnant women in the western part of Nigeria Parinari polyandra, Blighia sapida and Xylopia aethiopica were evaluated through their proximate compositions as well as percentage mineral elements composition. Blighia sapida was high in crude fibre (44.09±2.20%) compared with Parinari polyandra and Xylopia aethiopica that were 4.21±1.10% and 12.14±0.70% respectively. Moisture contents of Xylopia aethiopica and Blighia sapida were 16.04±1.25% and 10.17±2.60% respectively while that of Parinari polyandra was 30.65±5.02%. The total ash contents of Parinari polyandra, Blighia sapida and Xylopia aethiopica were 2.53±1.20%, 3.66±1.20% and 4.37±0.85% respectively. The total fat of Xylopia aethiopica, Blighia sapida and Parinari polyandra were 9.55±2.10%, 1.25±0.20% and 0.53±0.15% respectively while the total protein of Blighia sapida, Xylopia aethiopica and Parinari polyandra were 2.1±0.25%, 2.1±0.20% and 7.09±0.20% respectively. The total carbohydrate of Xylopia aethiopica was 55.80±4.26%, that of Parinari polyandra was 54.27±3.20% and that of Blighia sapida was 39.45±2.20%. Xylopia aethiopica can be a good source of magnesium (2.236±0.095), phosphorus (0.620±0.04) and potassium (0.510±0.04) as the amount of these mineral elements were higher than that of the other plant parts with the exception of Parinari polyandra having 0.690±0.11% phosphorus. Blighia sapida is also a good source of phosphorus (0.400±0.20), magnesium (0.430±0.20) and calcium (0.348±0.15). Other mineral elements detected in reasonable amounts were calcium, zinc and sodium. Further tests revealed that heavy metals such as lead, chromium and cadmium were not detected. The results of this research indicated that the three plants parts have nutritional qualities that could provide the users with additional nutrients.
  A.O. Abolaji , A.H. Adebayo and O.S. Odesanmi
  The effects of the ethanolic fruit extract of Parinari polyandra on lipid profile and electrolyte levels in pregnant rabbits were investigated. Graded concentrations of 0, 10, 50 and 250 mg kg-1 body weight of the extracts were administered by gastric intubations for a period of 14 days from the 12th -25th day of gestation after which they were fasted for 18 h. The following lipid profiles were examined in the serum. Triglyceride, Total Cholesterol, High Density Lipoprotein (HDL) and Low Density Lipoprotein (LDL) cholesterol. Serum electrolytes also examined were: Sodium (Na+), Potassium (K+), Calcium(Ca2+), Chloride (Cl¯), Bicarbonate(HCO3¯) and Phosphorus (P). After these durations of treatment, there was significant elevation in triglycerides (p<0.01). The LDL/HDL Cholesterol ratio was greater than 0.3 in all the treated groups. Also, there were significant elevations in Na+ (p<0.05), Cl-(p<0.05), P (p<0.05) and Ca2+ (p<0.05). The result therefore suggests that the ethanolic fruit extract of Parinari polyandra may predispose to hyperlipidemia and electrolytes imbalance leading to hypercalcaemia and high risk of raised blood pressure in pregnant rabbits.
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