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Articles by A.E. Oji
Total Records ( 2 ) for A.E. Oji
  I.R. Iroha , A.E. Oji , O.K. Nwosu and E.S. Amadi
  The antimicrobial activities of Savlon®, Izal® and Z-Germicide® disinfectants against 23 clinical isolates of Pseudomonas aeruginosa were evaluated. The agar well diffusion technique and broth dilution technique for determining Minimum Inhibitory Concentration (MIC μg mL-1) were employed. The overall result of the study showed that Savlon® and Izal® have appreciable antimicrobial activity against the P. aeruginosa isolates, while Z-Germicide® produced low activity. The use of Savlon® and Izal® disinfectants in hospitals and clinics in Nigeria, is hereby suggested.
  I.R. Iroha , E.S Amadi , J.O. Orji , A.C. Ogabus , A.E. Oji and C.O. Esimone
  The present study evaluated the antimicrobial effect of different combinations of gentamicin and floroquinolones (ciprofloxacin, ofloxacin, perfloxacin and gatifloxacin) against extended spectrum beta lactamase (ESBL) positive E. coli isolates using checkerboard method. One hundred and four clinical isolates of E. coli obtained from urine (26), blood (24), stool (20), sputum (19) and semen (14) were investigated for ESBL production. Fifteen (14.4%) were positive for ESBL production in the following order: 4(3.8%) from urine, 3(2.8%) from blood, 3(2.8%) from stool, 3(2.8%) from sputum and 2(1.9%) from semen. Five representative ESBL positive isolates, one from each specimen, were investigated for their susceptibility patterns to different gentamicin and floroquinolone combinations. The combinations of gentamicin and ciprofloxacin, perfloxacin and gatifloxacin, respectively at different ratios were predominantly synergistic in activity while gentamicin and ofloxacin combinations were primarily indifference in activity. These results may have some therapeutic significance in the management of ESBL infections especially in areas of the world where ESBL organisms are either emerging or re-emerging.
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