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Articles by A.C. Nwuzo
Total Records ( 1 ) for A.C. Nwuzo
  I.B. Moses , C.O. Esimone , I.R. Iroha , E.N. Ugbo , A.C. Nwuzo , J.O. Orji , E.A. Nwakaeze , N.B. Agumah , A.A. Emioye , E.G. Ukpai and L.N. Ogene
  Background and Objective: The increase in antibiotic-resistant Staphylococcus pseudintermedius among pets and the transfer of S. pseudintermedius from pets to humans threaten veterinary medicine and public health. The objective of this study was to determine the antibiotic resistance patterns and prevalence of virulence genes among Staphylococcus pseudintermedius isolates obtained from dogs and dog owners in Abakaliki, Nigeria. Materials and Methods: Swab samples from 112 shelter dogs and 97 dog owners were processed using standard microbiological procedures. Antibiotic susceptibility test was done by Kirby Bauer disc diffusion technique. Screening for virulence genes was done by Polymerase Chain Reaction (PCR). Results: Exactly 99 S. pseudintermedius isolates including 52 Methicillin Resistant Staphylococcus pseudintermedius (MRSP) strains were recovered from dogs and humans. Sec, exi, siet and lukD virulence genes were confirmed by PCR. Isolates were highly resistant (69.2-100%) to amoxicillin, cefepime and ceftazidime, but very susceptible (66.3-80.2%) to ofloxacin, doripenem, ertapenem and chloramphenicol. A total of 73 (73.7%), 2 (2%), 62 (62.6%) and 55 (55.6%) isolates harboured sec, exi, siet and lukD virulence genes, respectively. Conclusion: Isolates in this study harboured sec, siet, exi and lukD virulence genes and were also notably more resistant than those reported in literature. There was phenotypic homogeneity in the antibiotic resistance profiles of isolates from both humans and dogs in households that were sampled, thus depicting a possible zoonotic transmission event from dogs to their owners. Hence, monitoring of antimicrobial resistance, appropriate hygienic measures such as; hand washing after attending to dogs should be adopted so as to minimize the spread of resistance and virulence.
 
 
 
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