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Articles by A.C. Das
Total Records ( 2 ) for A.C. Das
  S.K. Biswas , A. Chowdhury , J. Das , U.K. Karmakar , S.Z. Raihan , A.C. Das , M.A. Hannan , M.A. Monsur Dinar , M.J. Hassan , M.I. Hossain and M.R. Farhad
  Cuscuta epithymum Murr. (Convolvulaceae) is found in Bangladesh and has been used in traditional medicine. The present study was designed to investigate the preliminary phytochemical screening, cytotoxicity and antibacterial activities of the methanol extract of the plant stem. The preliminary phytochemical analysis was performed on the basis of the standard procedures and thin layer chromatography to confirm the presence of chemical compounds in the methanol extract of the plant. The minimum inhibitory concentration and cytotoxic activities of the extract were carried out according to broth dilution assay and brine shrimp lethality bioassay, respectively. The results of preliminary phytochemical analysis showed the presence of flavonoid, glycoside, alkaloids, carbohydrates, saponins and steroids in the plant extract. In this study, the methanol extract was subjected to Thin Layer Chromatography (TLC) in order to detect the phytoconstituents present in the extract and the best result of TLC was obtained from the solvent system comprising of toluene and ethyl acetate at the ratio of 5.5:4.5 which identified the maximum number of spots. Moreover, the extract showed moderate antibacterial activities against Bacillus megaterium, Pseudomonas aeruginosa, Escherichia coli and Salmonella typhi with MIC values of 4.96±0.20, 3.03±0.16, 3.47±0.20 and 4.07±0.08 mg mL-1, respectively. The methanol extract showed lethality against brine shrimp nauplii (LC50: 36.31 μg mL-1 and LC90: 83.18 μg mL-1 ). The results indicated that the methanol extract of the stem of the plant possessed antibacterial and cytotoxic properties with several numbers of chemical compounds.
  S.Z. Raihan , M.M. Monir , P. Biswas , S.K. Biswas , A. Chowdhury , J. Das and A.C. Das
  Dalbergia spinosa Roxb. (Family: Fabaceae) has many traditional uses in Bangladesh. The crude methanol extract of the stem barks of D. spinosa Roxb. was investigated for possible antinociceptive activity using acetic acid induced writhing model in mice. Phytochemical analysis was also performed using standard procedures to detect the presence of phytochemicals in the crude plant extract. The study results showed 37.20% inhibition of writhings in the tested mice when methanol extracts were given intraperitoneally (i.p.) at the dose of 250 mg extract kg-1 b.wt. The maximum inhibition (40.01%) of nociception effect was achieved at 500 mg extract kg-1 b.wt., i.p. which was also compared with the antinociceptive activity of the standard drug, diclofenac sodium at the dose of 25 mg extract kg-1 b.wt. which produced 68.37% inhibition of nociception effect. The inhibition of writhings was calculated in respective to control group and it was found that p-values (<0.0001) calculated by student’s t-test were statistically significant. However, the phytochemical screening revealed the presence of alkaloid, steroid, flavonoid, tannin, reducing sugar and gum. Finally, it can be concluded that crude methanol extracts of D. spinosa stem barks contain biologically active phytoconstituents exhibiting significant dose-dependent antinociceptive activity in the mice model used. Thus, it is recommended to isolate and characterize the compounds for the development of new analgesics.
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