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Articles by A.A.A. Kayode
Total Records ( 8 ) for A.A.A. Kayode
  A.A.A. Kayode and O.T. Kayode
  Several medicinal uses of the fluted pumpkin (Telfairia occidentalis) in traditional medicine have been documented. Although, many of these claims are yet to be validated by scientific researchers, a review of some investigated therapeutic activities of the plant are highlighted in this article. Experimental works done on Telfairia occidentalis especially in the field of Biochemistry were retrieved via Google search on the internet and studied carefully to identify any therapeutic activity reported on Telfairia occidentalis. It can be inferred that the ability of the plant to combat certain diseases may be due to its antioxidant and antimicrobial properties and its minerals (especially Iron), vitamins (especially vitamin A and C) and high protein contents. We therefore conclude that with further chemical manipulation and clinical investigations numerous drug designs could emerge from the plant. An effort to keep the plant protected and conserved is also advocated.
  J.O. Babayemi , G.O. Adewuyi , K.T. Dauda and A.A.A. Kayode
  Local production of ash-derived alkali was assessed in this review. Detailed information on local production of ash-derived alkali is rare in literature. Hence, the technologies, materials, probable criteria for selection of materials, processes, use, limitations, problems and areas needing further research in the local production of alkali were assessed. Visitation was made to some traditional alkali-producing factories as well as interaction with other local alkali producer. The traditional technology was found very interesting, while the corresponding laboratory set-up showed an improvement over the traditional one. Local production of potash-an impure form of ash-derived alkali, was observed to be a cheap alternative source of this much needed chemical used in the production of soap and other alkali-based products.
  A.A.A. Kayode , O.T. Kayode and A.A. Odetola
  It has been observed and established that enhancing the antioxidant defense system during the early phase of rehabilitation is important to the survival of wasting protein energy malnourished patients. In this study, comparison was made between the efficacy of dietary protein replenishment and supplementation with Telfairia occidentalis leaves, in the treatment of oxidative brain damage in the malnourished rats. The protein energy malnourished rats were produced by feeding weanling rats a protein deficient diet (2% protein) for 28 days. The malnourished rats were then divided into three dietary treatment groups, 20% protein+10% T. occidentalis group (PTG), 20% Protein Group (PG) and the 10% T. occidentalis group (TG). Significant decrease in brain size (p<0.01), activity of superoxide dismutase (p<0.01), catalase (p<0.01) and increased Malondialdehyde levels (p<0.01), indicative of oxidative damage were observed in the malnourished rats as compared with the control group. Reduced level of oxidative damage was however observed in group TG, PG and PTG , respectively. The result indicates that T. occidentalis leaves supplementation with protein repletion is more effective for recovery from protein energy malnutrition induced oxidative damage in rats than protein repletion alone.
  O.T. Kayode , O.A. Afolayan , A.A.A. Kayode and H.A. Mohammed
  Background and Objective: Imported chicken meat is smuggled into the country through the porous borders of Idiroko road which leads into Ota, Ogun State and sold to retailers in the open market. This study was carried out to assess and compare the nutritional composition and safety profile of the imported frozen, exotic commercial and indigenous chicken meats consumed in Ota metropolis. Materials and Methods: A total of 21 chicken meat samples were used for the study. Group 1, 2 and 3 comprise of seven samples each of imported frozen, exotic commercial and local chicken meat, respectively. The samples were digested and nutritional composition assessed by determination of proximate composition and essential elemental analysis. The safety profile was determined by quantification of levels of heavy metals (cadmium, lead and chromium), malondialdehyde and lipid profile of the chicken meats. Data analysis was done using SPSS version 15.0. The level of significance was set at p<0.05. Results: The proximate composition revealed significantly higher (p<0.05) levels of food nutrients in groups 2 and 3 compared to group 1. Similarly, the elemental analysis showed that groups 2 and 3 had significantly higher (p<0.05) levels of the elements and their concentration is within permissible limits compared to group 1 with significantly higher levels (p<0.05) of heavy metals such as lead, chromium and cadmium. Furthermore, the lipid profile analysis revealed significant increase (p<0.05) in levels of Low-Density Lipoprotein-Cholesterol (LDL-C), triglyceride and total cholesterol in the group 1 samples while group 3 has significantly higher levels (p<0.05) of High-Density Lipoprotein-Cholesterol (HDL-C). Malondialdehyde levels were also significantly higher in the group 1 samples compared to groups 2 and 3. Conclusion: The local and exotic commercial chicken meat are more nutritious and safer for consumption compared to the imported chicken meats sold in Ota, Ogun state.
  J.O. Babayemi , K.T. Dauda , D.O. Nwude and A.A.A. Kayode
  The composition and chemistry of ash and potash from various plant materials were assessed. Sequel to unavailability of vital information on the composition and chemistry of ash and potash is the production of potash of low quality, especially by local producers, as well as wrong determination or identification and quantification of components of potash in studying it for various purposes. In this review, both qualitative and quantitative chemistry of ash and potash as well as factors affecting them were evaluated; disparities in observations in previous studies were identified and clarified. The results indicated variable compositions, definite chemistry influenced by several factors and different ideas and observations of various researchers.
  O.T. Kayode , A.A.A. Kayode and O.O. Awonuga
  There has been high incidence of malaria and typhoid co-infection in Nigeria lately but no documented study has really considered its impact on the biochemical status of the patients. The aim of this study was to investigate the effect of malaria and malaria-typhoid co-infection on some hematological and biochemical parameters in infected patients. A total of 66 febrile patients and 10 apparently healthy persons from Bells University of Technology and Covenant University Health Centers, Ota, Ogun State were screened for the presence of plasmodium falciparum and salmonella typhi. Levels of Neutrophils, Lymphocytes, White Blood Cells, Packed Cell Volume (PCV), Albumin, Urea, Glucose, Total Bilirubin, Total Protein and Creatinine were estimated in the blood plasma of the study groups. A significant increase (p<0.05) in Creatinine, Urea and Total Bilirubin levels, Neutrophils and White Blood Cell counts were observed in both the malaria and co-infected patients as compared to the control. However, Albumin, Glucose, PCV, Lymphocytes and Total Protein levels were significantly reduced (p<0.05) in both the malaria and co-infected patients. This study indicates alterations in these parameters and therefore recommends proper monitoring during treatment in order to reverse them to normal levels.
  A.A.A. Kayode , O.T. Kayode , O.A. Aroyeun and M.C. Stephen
  The aim of this study was to assess the effects of short-term administration of some antiretroviral drugs on hematological and hepatic parameters in albino rats. The rats were treated with 0.43, 0.43, 0.27 and 0.21 mg kg-1 of Efavirenz, Abacavir, SNP 40 and Lamivudine respectively, for seven days. The control group received normal saline. On the eighth day, the rats were sacrificed; blood and liver were collected for White Blood Cell Count (WBC), Packed Cell Volume (PCV), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) analysis. All the drugs showed significant increase (p<0.05) in %WBC (43.0, 42.6, 52.3 and 37.4%) for Efavirenz, Abacavir, SNP 40 and Lamivudine respectively. Abacavir, SNP 40 and Lamivudine significantly decreased (p<0.05) ALP by 66.67, 84.75 and 56.24%, respectively while Efavirenz and Abacavir caused significant increase and decrease (p<0.05) in AST by 9.09 and 16.36% respectively. Efavirenz, Abacavir and Lamivudine caused significant increase (p<0.05) in ALT by 321.6, 497.6 and 177%, respectively. The drugs significantly increased the immunity of the animals and Efavirenz, Lamivudine and Abacavir caused hepatic damage. The clinical implication of our findings is that hepatoprotective agents should be included in the treatment regimen when administering antiretroviral drugs such as Efavirenz, Lamivudine and Abacavir.
  A.A.A. Kayode , O.T. Kayode and A.A. Odetola
  The effect of two extracts of Parquetina nigrescens on mucosal antioxidants defense system in ethanol-induced ulcer in rats was studied. Activities of superoxide dismutase (SOD), catalase (CAT) and levels of reduced glutathione (GSH) were determined in the gastric mucosa and liver of normal and experimental groups of rats. The rats were pretreated with 500 and 1000 mg kg-1 of hexane and chloroform extracts of P. nigrescens, respectively dissolved in olive oil for a period of 14 days prior to ethanol induction. It was found that prior to ulcer induction, 14 days pretreatment with hexane and chloroform extract P. nigrescenes significantly reduced ethanol-induced gastric damage. The levels of GSH and activities of the antioxidants enzymes (SOD and CAT) were depressed significantly (p<0.05) in the ulcerated rats when compared with that of normal control. The activity of SOD was lower significantly (p<0.05) in the ulcerated mucosa and liver of the experimental rats when compared to the normal control group. There was a significant increase (p<0.05) in the level of CAT in the groups pretreated with the extracts compared to the ethanol group. A similar result was observed for GSH. Pretreatment with hexane extract caused 75.43 and 74.55% elevations in the activities of SOD in the mucosa and liver homogenate, respectively. Similar elevations were observed in the group pretreated with the chloroform extract. The cimetidine group also caused 69.79 and 69.67% elevation in the SOD activity in the mucosa and liver homogenate, respectively. The pretreatment with P. nigrescens was found to exact a significant gastro protective and antiulcer effect partly by protecting against the ethanol-induced ulcerogenic effects in experimental rats and probably through the induction of antioxidant enzymes.
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