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Articles by A.A. Odetola
Total Records ( 5 ) for A.A. Odetola
  A.A.A. Kayode , O.T. Kayode and A.A. Odetola
  It has been observed and established that enhancing the antioxidant defense system during the early phase of rehabilitation is important to the survival of wasting protein energy malnourished patients. In this study, comparison was made between the efficacy of dietary protein replenishment and supplementation with Telfairia occidentalis leaves, in the treatment of oxidative brain damage in the malnourished rats. The protein energy malnourished rats were produced by feeding weanling rats a protein deficient diet (2% protein) for 28 days. The malnourished rats were then divided into three dietary treatment groups, 20% protein+10% T. occidentalis group (PTG), 20% Protein Group (PG) and the 10% T. occidentalis group (TG). Significant decrease in brain size (p<0.01), activity of superoxide dismutase (p<0.01), catalase (p<0.01) and increased Malondialdehyde levels (p<0.01), indicative of oxidative damage were observed in the malnourished rats as compared with the control group. Reduced level of oxidative damage was however observed in group TG, PG and PTG , respectively. The result indicates that T. occidentalis leaves supplementation with protein repletion is more effective for recovery from protein energy malnutrition induced oxidative damage in rats than protein repletion alone.
  O.R. Aderibigbe , A.A. Odetola , F.S. Oluwole , E.O. Farombi , O.O. Onabanjo and O.A. Jiboku
  Parquetina nigrescens is a plant used in folk medicine in treating gastric ulcer. This study investigated the antioxidant properties of P. nigrescens in ethanol ulcerated rats. Rats were pretreated for 7 or 14 days with graded doses (500 and 1000 mg kg-1) of methanol extract of P. nigrescens before ulcer was induced on 8th or 15th day with absolute ethanol (1 mL/rat). The antioxidant properties of P. nigrescens were assessed using standard procedures. Intoxication with ethanol caused increased lipid peroxidation, reduced activities of Super Oxide Dismutase (SOD) and Catalase (CAT) and reduced protein concentration. Pretreatment with P. nigrescens, however, lowered lipid peroxidation, caused increases in activities of SOD, CAT and protein levels. This study therefore, shows that P. nigrescens possesses antioxidant properties that can protect against free radical induced ulcer.
  A.A. Oyagbemi and A.A. Odetola
  The study was designed to evaluate the possible hepatoprotective effect of Cnidoscolus aconitifolius on paracetamol poisoning in rats. Twenty five male Wistar rats were used in this study. They were divided into 5 groups of 5 rats. Groups I and II received normal saline (0.9% physiological saline). Animal in groups III-V were administered Cnidoscolus aconitifolius at 100, 500 and 1,000 mg kg-1, respectively for 7 days. All animal in groups II-V were given paracetamol at 3 g kg-1 by gastric gavage on days 8 and 9. Animals were sacrificed by cervical dislocation on day 10 after an overnight fast. Paracetamol overdose caused significant (p<0.05) increase in the plasma Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP), Blood Urea Nitrogen (BUN), triglycerides (TAG) and total cholesterol (TC) and Low Density Lipoprotein (LDL-cholesterol) and significant (p<0.05) decrease Total Protein (TP) and High Density Lipoprotein (HDL-cholesterol) in rats treated with paracetamol alone when compared with rats pre-treated with extract of Cnidoscolus aconitifolius. Pre-treatment with ethanolic extract of Cnidoscolus aconitifolius led to significant (p<0.05) decrease in serum ALT, ALP, AST, LDL and BUN when compared with the paracetamol treated rats in dose-dependent manner. The extract also similarly caused significant (p<0.05) increase in HDL values compared with paracetamol treated group. In conclusion, the results of this study demonstrated that the Cnidoscolus aconitifolius can ameliorate paracetamol-induced hepatotoxicity. Significant hepato-protective activity was observed in rats treated with the dose of 1000 mg kg-1 b.wt.
  O.T. Kayode , A.A. Kayode and A.A. Odetola
  Comparison was made between the efficacy of dietary protein replenishment and supplementation with Telfairia occidentalis leaves, in treatment of Protein Energy Malnutrition (PEM) induced liver damage. PEM rats were produced by feeding weanling rats a protein deficient diet (2% protein) for 28 days and then divided into four dietary treatment groups: 2% protein (group A; PEM control group); 20% protein and 10% T. occidentalis (group C); 20% protein (group D) and 10% T. occidentalis (group E). The protein deficient diet caused a significant increase (p<0.01) in hepatic malondialdehyde (MDA) level and the liver function enzymes alkaline phosphatase (ALP), alanine amino transferase (ALT) and aspartate amino transferase (AST) level in the serum. It also caused a marked reduction (p<0.01) in glutathione level, significant decrease (p<0.01) in the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) and significant damage to the hepatocytes. Recovery diets of protein alone and protein supplemented with T. occidentalis had significant effects on all the parameters. The MDA level and the serum liver function enzymes were significantly reduced (p<0.01), glutathione and antioxidant enzymes levels were markedly increased (p<0.01) and a highly significant hepatocyte healing observed in the histology images. The highest recovery was however observed in group C. Results indicate the restorative ability of T. occidentalis in treatment of oxidative stress induced liver damage in PEM rats.
  A.A.A. Kayode , O.T. Kayode and A.A. Odetola
  The effect of two extracts of Parquetina nigrescens on mucosal antioxidants defense system in ethanol-induced ulcer in rats was studied. Activities of superoxide dismutase (SOD), catalase (CAT) and levels of reduced glutathione (GSH) were determined in the gastric mucosa and liver of normal and experimental groups of rats. The rats were pretreated with 500 and 1000 mg kg-1 of hexane and chloroform extracts of P. nigrescens, respectively dissolved in olive oil for a period of 14 days prior to ethanol induction. It was found that prior to ulcer induction, 14 days pretreatment with hexane and chloroform extract P. nigrescenes significantly reduced ethanol-induced gastric damage. The levels of GSH and activities of the antioxidants enzymes (SOD and CAT) were depressed significantly (p<0.05) in the ulcerated rats when compared with that of normal control. The activity of SOD was lower significantly (p<0.05) in the ulcerated mucosa and liver of the experimental rats when compared to the normal control group. There was a significant increase (p<0.05) in the level of CAT in the groups pretreated with the extracts compared to the ethanol group. A similar result was observed for GSH. Pretreatment with hexane extract caused 75.43 and 74.55% elevations in the activities of SOD in the mucosa and liver homogenate, respectively. Similar elevations were observed in the group pretreated with the chloroform extract. The cimetidine group also caused 69.79 and 69.67% elevation in the SOD activity in the mucosa and liver homogenate, respectively. The pretreatment with P. nigrescens was found to exact a significant gastro protective and antiulcer effect partly by protecting against the ethanol-induced ulcerogenic effects in experimental rats and probably through the induction of antioxidant enzymes.
 
 
 
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