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Articles by A.A. Moazedi
Total Records ( 7 ) for A.A. Moazedi
  A.A. Moazedi , M. Belaran , A. Hemmaty and A. Rasekh
  This study was designed to evaluate the role of beta-adrenergic system on the enhancement of spatial learning caused by glucose injection in the Y-maze. Young male Wistar rats were given daily injections of glucose (500 mg kg-1, i.p.) 10 min before training, propranolol (20 mg kg-1, s.c.) 30 min before training and co-administration of glucose (500 mg kg-1) and propranolol (20 mg kg-1). Three sham groups were received saline at the same volume and conditions. Comparison between co-administration of glucose and propranolol and glucose groups, showed a significant differences at first (p<0.01), third (p<0.001), fourth (p<0.01) and fifth (p<0.001) days. Indeed, co-administration of glucose and propranolol caused impairment of spatial learning. There was no significant difference between propranolol and co-administered groups. These findings indicate that propranolol impairs improvement of spatial learning caused by glucose administration via blockade of beta-adrenergic receptors and thus it seems that glucose exerts its memory enhancing effects via beta-adrenergic receptors.
  A.A. Moazedi , Z. Valizadeh and Gh. A. Parham
  The aim of the present study was to investigate the effects intra-dorsal hippocampus (intraCA1) injection of NMDA receptor noncompetitive antagonists (MK-801) on memory retention using passive avoidance learning. The antagonist was administered pre and post-behavioral training. In the first experiment adult Wistar rats were given saline or MK-801 (1 μg rat-1) 10 min prior to training for 4 days, while in the second experiment saline or MK-801 (1 μg rat-1) were given immediately after training for 4 days. Post-training administration of MK-801 did not affects memory retention, in contrast to pre-training injection of MK-801 which decreased memory retention. The results suggest that pre-training injection of the non competitive antagonist NMDA receptor (MK-801) in hippocampus impaired learning and memory but post-training administration of MK-801 did not effect on learning and memory in passive avoidance learning task.`
  A.A. Moazedi , N. Dabir , M.K. Gharib Naseri and M.R. Zadkarami
  The aim of present study was to investigate the role of opioid and α-adrenergic receptors in antispasmodic activity of Ruta chalepensis (L.) hydroalcoholic extract (RCHE) in rat ileum contractions induced by KCl. A piece of ileum (2 cm) was dissected out from male Wistar rats and mounted in an organ bath containing air bubbled Tyrode solution (37°C). Isotonic Transducer is exceptionally sensitive and stable and connected to Harvard Universal Oscillograph (UK). The tissue was under 1 g initial tension and contractions were recorded isotonically. The RCHE was prepared by macerated with alcohol (70%). Ileum was contracted by KCl (60 mM) and cumulative concentrations of RCHE were applied (0.01-0.07 mg mL-1) before and after tissue incubation (30 min) with naloxon (1 μM) or phentolamine (1 μM). RCHE reduced KCl-induced contraction in a concentration dependent manner (p<0.001). However, tissue incubation with naloxone and phentolamine attenuated the spasmolytic effect of RCHE (p<0.001). We conclude that in the antispasmodic activity of RCHE, at least in part, the opioid and α -adrenergic receptors are involved.
  A.A. Moazedi , N. Dabir , M.K. Gharib Naseri and M.R. Zadkarami
  In this study, the effect of Ruta chalepensis on rat’s ileum contraction has been investigated because the hydroalcoholic extract of the leave of Ruta chalepensis, grown in Iran were investigated for pharmacological properties. Ruta chalepensis (Rue) is annual herb is used in the traditional medicine in Iran for intestinal disorder. In this study the effect of hydroalcoholic extract of Rue on isolated rat’s ileum contraction was investigated by KCl (60 mM). A segment of ileum was removed and suspended in 10 mL organ bath containing aerated Tyrode solution (37 °C, pH = 7.4).The responses were determined and recorded on isotonic transducer and Harvard Universal Oscillograph. The result demonstrate that the extract significantly reduced the ileum contraction induced by KCl (60 mM) in a dose dependent manner (n = 7, p<0.001). Also, adding extract before influence of KCl, cause reduce effect of KCl (n = 7, p<0.001). In another study, in high potassium Ca2+-free tyrode solution, cumulative concentrations of CaCl2, induced ileal contraction, however, the extract reduced these contractions in a dose dependently (n = 7, p<0.001). Therefore, the results suggest that relaxatory effect of rue on the ileum may be due to blocking of voltage gated calcium channels.
  A.A. Moazedi , M. Belaran , A. Hemmaty and A. Rasekh
  This study was designed to evaluate the influence of co-administered epinephrine and glucose on spatial learning in the Y-maze task. Young male wistar rats were given daily injections of epinephrine (0.1 mg kg1 30 min before training, sc), glucose (500 mg kg1 10 min before training, i.p.) and co-administration of epinephrine (0.1 mg kg1) and glucose (500 mg kg1). Sham groups received saline at the same volumes and conditions. The results showed that epinephrine significantly increase spatial learning at first (p<0.05), second (p<0.05), third (p<0.01) and fourth (p<0.05) days. Also, spatial learning improve at first (p<0.05) day in glucose group. Comparison between co-administration epinephrine and glucose and epinephrine groups were significant in first day (p<0.001). No synergic effect observed on the enhancement of spatial learning task in co-administration of epinephrine and glucose.
  A.A. Moazedi , D.N. Mirzaie , S.M. Seyyednejad , M.R. Zadkarami and A. Amirzargar
  Traditional herbal medicines such as Petroselinum crispum (Parsley) have been used for treatment of intestinal disorders in Iran. To date no pharmacological evidence for their effectiveness has been reported. The aim of this study was to examine the relaxant effect of hydroalcoholic extract of Petroselinum crispum on isolated adult male Wistar rat’s ileum contraction by KCl 60 (mM). The extract was prepared from parsley seed with 80% ethanol. A portion of ileum was removed and placed in an organ bath containing Tyrode solution (37° C, pH = 7.4) bubbled with air. From a resting tension of 1 g, isotonic Transducer and Harvard Universal Oscillograph were used for recording contraction of ileum after administration of 60 mM KCl. Various concentration of extract were added to the bath. This experiment showed that, the extract in a dose-dependent manner decreased the induced-KCl ileums contraction (n = 7, p<0.001). Also adding extract before influence of KCl, cause reduced effect of KCl (n = 7, p<0.001). In addition, the Tyrode solution without CaCl2 and high concentration of K+, various concentration of extract significantly (n = 7, p<0.001) decreased the CaCl2-induced contraction. Therefore, it seems that the relaxation effect of extract alcoholic parsley seed on the contraction of ileum is performed by blocking of voltage-gated calcium channels.
  A.A. Moazedi , N. Dabir , M.K. Gharib Naseri and M.R. Zadkarami
  The aim of present study was to investigate the effect of hydroalcoholic extract of Ruta chalepensis (Rutaceae) leaves on rat ileum contractility and possible mechanism(s) involved. Ruta chalepensis extract was prepared by maceration method (ethanol 70%). Terminal portion of ileum (2 cm) was dissected out from male Wistar rats and mounted in an organ bath containing air bubbled Tyrode solution with 1 g initial tension and ileal contraction induced by KCl (60 mM) was recorded. The spasmolytic effect of the cumulative concentrations of extracts (0.01- 0.07 mg mL-1) was reduced after tissue incubation with L-NAME (100 μM, 20 min). Methylene blue (30 μM) reduced the extracts (0.01-0.07 mg mL-1) spasmolytic effect (p<0.001). Furthermore, it seems that the portion relaxatory effect of Rue extract on the rat ileum may be due to nitric oxide and the antispasmodic activity of the extract was mainly through a cGMP-dependent mechanism.
 
 
 
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