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Articles by A.A. Akintola
Total Records ( 3 ) for A.A. Akintola
  R.O. Arise , A.A. Akintola , J.B. Olarinoye and E.A. Balogun
  The study was carried out to investigate effects of administration of aqueous extract of Nauclea latifolia stem on lipid profile and some liver and kidney parameters of rat. Thirty rats were grouped into five. Each group consisting of six rats each. Group 1 served as the control and was administered 2 mL distilled water. The remaining groups were administered 200, 400, 600 and 800 mg kg-1 b.wt. of aqueous extract of Nauclea latifolia stem, respectively. Administration lasted for twenty eight days during which three rats from each group were sacrificed twenty four hours after administration on the fourteenth day and the remaining, twenty eighth day. Liver, kidney and blood were collected and alkaline phosphatase, alanine aminotransferase, aspartate amino transferase, urea, creatinine, malondialdehyde level as well as lipid profile evaluated. The results showed a significant (p<0.05) concentration dependent decrease in total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) and increase in low density lipoprotein cholesterol (LDL-C) and triglycerides (TG) at both periods. Similar results were obtained in serum concentration of creatinine and urea with TC and HDL-C. There was significant concentration dependent reduction (p<0.05) in liver and kidney alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase activities with a corresponding significant increase (p<0.05) in their serum activities. This revealed a time and concentration dependent hepatotoxic and nephrotoxic potentials of the aqueous extract of Nauclea latifolia stem.
  S.J. Josiah , S.C.O. Nwangwu , A.A. Akintola , U. Usunobun , F.S. Oyefule , O.K. Ajeigbe and A. Akinola
  The protective role of ethanolic extract of Vernonia amygadalina against potassium bromate induced tissue damage in Wistar rats was investigated. Twenty rats were divided into four groups of five rats each (A, B, C and D). Group A was administered 1 ml of 0.25 M sucrose solution. Group C and D were pretreated with 250 mg/kg and 500 mg/kg body weight of the aqueous extract of V. amygdalina respectively. The oral induction of 60 mg/kg potassium bromate to groups B, C and D were done eight hours before sacrifice. The liver, spleen, brain, kidney, heart and stomach were collected. Organ-body weight ratio, total tissue protein, amino acid level and malondialdehyde level in the tissues were estimated. The result showed a significant increase in all the parameters studied in group B. The organ to body weight ratio, total protein level, MDA concentration significantly lowered at both doses and amino acid level reduction is significant (p<0.05) in Group C when compared with Group B. This suggested that ethanolic extract of Vernonia amygdalina has a protective potential against tissue damage induced by potassium bromate.
  A.K. Arise , R.O. Arise , A.A. Akintola , O.A. Idowu and O.C. Aworh
  The aim of this study was to investigate the microbial load and evaluate the nutritional content and sensory property of traditional sun dried okra (“orunla” - Yoruba, Nigeria). Samples were purchased from four different markets at different time in South-western Nigeria. Microorganisms present in the samples were analyzed on nutrient agar, potato dextrose agar and malt extract. Proximate evaluation of the sun dried okra was also carried out to determine the protein, ascorbic acid, ash and crude fibre contents. Nutritional evaluation revealed considerable amount of measured nutrient without significant difference (p>0.05) inspite of the time and place of purchase. Sensory evaluation of the samples showed that they were generally acceptable to a taste panel. Microbial study identified Staphylococcus aureus, Aspergillus niger, Aspergills tamari, Fusarium compactum, Rhizopus nigricans and Bacillus lichiniforms as some of the microorganisms present in the sun-dried vegetable. This study thus, suggested that sun-dried okra could be consumed but when processed under control microbial condition.
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