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Articles by A.A. Odetola
Total Records ( 3 ) for A.A. Odetola
  A.A. Odetola , F.S. Oluwole , B.A. Adeniyi , A.M. Olatiregun , O.R. Ikupolowo , O. Labode , K.O. Busari and J.A. Shorinola
  Leaf extracts of Parquetina nigrescens (AAfz.) Bullock, a plant commonly employed for the treatment of gastro-intestinal disorders in Nigeria was tested for antimicrobial activity and gastro-intestinal protective effect. Aqueous leaf extract showed antimicrobial activity against a range of bacteria in the following order of activity: Staphylococcus aureus > Salmonella typhi > Proteus mirabilis > Pseudomonas aeruginosa > Bacillus subtilis > Proteus vulgaris, whereas the ethanol extract was effective only against Pseudomonas aeruginosa and Salmonella typhi. The aqueous extract also significantly reduced gastric acid secretion, reduced ethanol-induced gastric ulceration (p<0.05) and caused elevation in gastric mucus secretion. The antimicrobial activity against the common pathogenic microbes S. aureus, S. typhi and P. aeruginosa may account for its acclaimed potency against diarrhea. In addition, its protective effect against oral administration of absolute ethanol reflected by the increased mucus secretion and decreased gastric acid secretion may also be responsible for its claim as having anti-ulcer property.
  G.A. Agbor and A.A. Odetola
  The effect of graded doses of aqueous leaf extract of Parquetina nigrescens on erythrocyte indices and serum electrolytes was studied for two weeks on rats following acute blood loss. Red blood cell count, haemoglobin concentration, haematocrit, reticulocyte population and erythrocyte osmofragility were used as erythrocyte indices. The plasma electrolytes concentrations of sodium, potassium, calcium and bicarbonate were analysed. Parquetina nigrescens significantly (p < 0.05) increased the erythrocyte indices which were initially reduced by bleeding except for erythrocyte osmofragility which instead decreased significantly (p < 0.05). Parquetina nigrescens had no effect on serum electrolyte except for sodium ion concentration which increased significantly (p < 0.05). The improved erythrocyte indices and reduced erythrocyte osmofragility are indications of erythropoietic potential of Parquetina nigrescens.
  A.A. Odetola , Y.O. Iranloye and O. Akinloye
  The fresh, ripe fruits of Solanum melongena and Solanum gilo were investigated for their possible hypolidemic potentials in hypercholesterolemia induced in New Zealand white rabbits by feeding the animals with normal diet supplemented with 1% cholesterol and groundnut oil for 3 weeks. Hypercholesterolemic rabbits were thereafter treated with normal diet supplemented with 10% of each fruit for 6 weeks. Rabbits fed with normal diet and hypercholesterolemic diets through out the experiment were used as negative and positive controls respectively. There was a significant increase in the weight of hypercholesterolemic rabbits, both test (Groups D & E) and control (Groups B and C) (P<0.01) compared with normal control (Group A). It was observed that the hypercholesterolemic rabbits treated with normal diet elicited a significant reduction in fasting serum cholesterol (11.52%), triglyceride (16.5%) and LDL cholesterol (41.13%) but a significant increase in HDL cholesterol (16.48%) and also in the HDL/LDL ratio (1.10), four weeks after replacement of high cholesterol diet with normal diet. This positive response was however more pronounced in fruits treated rabbits. Solanum melongena and Solanum gilo significantly reduced serum total cholesterol by 65.40 and 52.69% respectively, triglyceride by 47.7 and 27%, LDL cholesterol by 85 and 83% respectively. They also increased significantly serum HDL by 24.7 and 25% respectively leading to increased HDL/LDL cholesterol ratio (3.37 and 3.25 respectively). This trend was also similar with liver lipid levels. Histopathological examination of the liver and aorta paraffin section stained with Haematoxylin & Eosine showed fewer lesions in the hypercholesterolemic rabbits treated with Solanum fruits compared with control hypercholesterolemic rabbits. These observations demonstrated that Solanum melongena and Solanum gilo have strong hypolipedemic effect which combined with improved HDL/LDL ratio is an indication of the possible use of this fruit in the treatment of diseases associated with hyperlipidemia such as ishcaemic heart diseases and arteriosclerosis.
 
 
 
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