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Articles by A.A. Ebbo
Total Records ( 3 ) for A.A. Ebbo
  S.W. Hassan , R.A. Umar , M. Lawal , L.S. Bilbis , B.Y. Muhammad , U.Z. Faruk and A.A. Ebbo
  The alkaloidal composition, histopathological and toxicity studies of alkaloid and aqueous ethanol extracts of Boscia angustifolia on biochemical indices of kidney and liver functions in rats were studied. The amount of alkaloids detected in 50 g powdered root extract of the plant was 11.44% (w/v). Renal and liver indices were significantly (p<0.05) altered at higher doses of 703.60, 1125.70 (alkaloidal extract), 839.30 and 1342.80 mg kg-1 body weight (aqueous ethanol extract). The aqueous ethanol and alkaloidal root extracts produced histopathological lesions of the liver and kidney at higher doses. These lesions include perivascular cuffs, protein cast, infiltration (kidney) and slight infiltration and perivascular cuffs (liver). There was a significant (p<0.05) dose dependent decrease in weight in the rats given higher doses of the aqueous ethanol and alkaloidal root extracts of Boscia angustifolia. The use of this plant is associated with some levels of organ toxicity.
  S.W. Hassan , R.A. Umar , M.J. Ladan , P. Nyemike , R.S.U. Wasagu , M. Lawal and A.A. Ebbo
  This study was aimed to assess the nutritive value, phytochemical constituents and antifungal activity of leaf, root and stem extracts of Pergularia tomentosa. Chemical composition of leaf, stem and root extracts of the plant were determined using standard methods. Aqueous and organic solvents extracts of the plant parts were screened for antifungal activity using agar dilution method. Phytochemicals detected in the leaf and stem extracts were alkaloids, cardiac glycosides, cyanogenic glycosides, saponins, flavonoids, tannins and anthraquinones. The roots contain trace amounts of cyanogenic glycosides, cardiac glycosides, saponins, tannins and anthraquinones. Mineral element composition of the plant showed higher amount of phosphorus and potassium in the root and stem and sodium, magnesium and calcium in the leaf extracts. All the plant parts used contain high percentages of carbohydrates and crude fibre ranging from 53.27±1.75 to 61.31±2.84% and 16.33±0.29 to 23.17±0.58%, respectively. Lipids (6.83±0.76%), ash (17.17±1.04%) and crude protein contents (6.39±0.17%) were higher in the leaf extracts while the stem was of higher moisture (10.67±0.76%) content. Hexane (HX), Petroleum Ether (PE) and chloroform (CHL) leaf, stem and root extracts were active against all the isolates tested with percentage inhibitions ranging from 41.90±5.63 to 97.52±0.28%. The organic solvent extracts demonstrated near complete inhibitions of the fungal isolates at 8.00 mg mL-1 while the aqueous (AQ) extracts of the plant parts inhibited the growth of the isolates at 27.17±7.79 to 97.45±0.21% with near complete inhibition of the tested isolates also at 8.00 mg mL-1. The results showed that the leaf, root and stem extracts of Pergularia tomentosa have potential nutritional and antifungal uses.
  S.W. Hassan , M.J. Ladan , R.A. Dogondaji , R.A. Umar , L.S. Bilbis , L.G. Hassan , A.A. Ebbo and I.K. Matazu
  The leaves of Erythrophleum africanum is known in the arid land of tropical Africa to posses toxicological properties. Phytochemical, acute and sub-acute evaluation of the possible toxicity risk of E. africanum aqueous leaves extracts were investigated in this study. Phytochemical constituents detected in the leaves extracts were saponins (1.16% w/v), cardiac glycosides, tannins (0.17 true tannins and 0.23% w/v pseudotannins), flavonoid glycosides, free flavonoids and alkaloids (4.34% w/v). The Lethal Dose (LD50) of the aqueous leaves extracts was greater than 3000 mg kg-1 per os (orally) in albino rats. Sub-acute administration of the extract for 28 days resulted in significant (p<0.05) changes in some renal and liver indices at 3000 and 2000-3000 mg kg-1 body weight, respectively. Histopathological lesions of the kidney and liver in form of moderate and marked infiltration with necrosis and perivascular lymphocytic cuff were observed. The observed lesions could be due to roles played by liver and kidneys in metabolism of xenobiotics and their elimination from the body. These investigations thus seem to indicate the toxic effects of the aqueous leaves extracts of E. africanum at 2000-3000 mg kg-1. These could be attributed to the combined toxicity of the phytochemical constituents such as tannins, saponins, glycosides and alkaloids.
 
 
 
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