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Articles by A. Zulkhairi
Total Records ( 3 ) for A. Zulkhairi
  F.A. Khairunnuur , A. Zulkhairi , I. Hairuszah , A. Azrina , I. Nursakinah , F. Fazali , M.N.H. Kamal , M.S. Zamree and K.A.K. Kamilah
  The global prevalence of overweight and obesity has reached epidemic proportions. Hyperlipemia couple with increased oxidative stress generates various degenerative diseases such as hypertension and cardiovascular problems. In the present study, a hypolipemic and weight reducing effects of crude Tamarindus indica L. pulp extract were examined in adult Sprague-Dawley rats fed a high-fat diet. Animals were fed on either normal chow or high-fat diet for 10 weeks for obesity induction and subsequently received either placebo or T. indica L. extract at 5, 25, 50 or 300 mg kg-1 chitosan via oral gavage for another 10 weeks. Treatment of obese rats with the T. indica pulp extract led to a decrease in the levels of plasma total cholesterol (TCHOL), low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) and increase high-density lipoprotein cholesterol (HDL-C) level with concomitant reduction of body weight. The extract improved the efficiency of the antioxidant defense system, as indicated by increased superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and subsequently resulted in significantly lower lipid peroxidation indices; malondialdehyde (MDA) level. Together these results indicate the potential use of T. indica extracts as hypolipemic and antioxidative agent apart from its ability to reduce body weight in obese-induced rats.
  M. Kamal NH. , A. Zulkhairi , A.H. Hafizah , F. Fazali , A.K. Khairul Kamilah , M.A. Rasadah , M.S. Zamree and M.A.M. Shahidan
  Endothelial cell injury due to inflammation and oxidative stress are the hallmark of early pathologic events of atherosclerosis. Antioxidants derived from natural sources have been extensively used to prevent oxidative stress. The purpose of this study was to investigate the cytoprotective effect of Anacardium occidentale Aqueous Extract (AOE) against H2O2-induced HUVEC injury and its anti-inflammatory potential induced by TNF-α in vitro. HUVEC was exposed with various concentrations of H2O2 (0-700 μM) and it was observed that 250 μM of H2O2 reduced cell viability by 50% (IC50) as denoted by MTT assay. Using the above concentration as the PC, the cells were pretreated with AOE at various concentration (50-700 μg mL-1) for 30 min followed by 24 h incubation with H2O2 (250 μM) or TNF-α (10 ng mL-1), respectively. AOE was found to be not toxic to the cells as no inhibitory concentration (IC50) obtained. AOE (100-300 μg mL-1) protects cellular damage and prevent microsomal lipid peroxidation in H2O2-induced HUVEC indicated with low MDA levels. The AOE at similar concentrations also suppressed the production of VCAM-1, ICAM-1, MCP-1 and M-CSF in TNF-α-induced inflammation whereas NF-κB p65 translocation into nucleus was observed inactivated. These data suggested that AOE possessed antioxidative properties and attenuate the initial stage of atherogenesis in vitro. Inhibition of NF-κB activation could be the possible underlying mechanism in modulating early events of atherogenesis.
  F. Fazali , A. Zulkhairi , M.E. Nurhaizan , N.H. Kamal , M.S. Zamree and M.A. Shahidan
  Oxidative stress has been shown to play important role in the development of various diseases. In this study, researchers investigated the existence of phytochemical constituents of Anacardium occidentale Linn. (AO) leaf and evaluate its in vitro and in vivo antioxidant activities in aqueous extract form. Phytochemical screening of AO was performed according to the standard method while in vitro antioxidant activities were performed via DDPH free radical scavenging and Ferric reducing antioxidant power assay. In vivo antioxidant activities were evaluated in hypercholesterolemic induced adult male New Zealand white rabbits. Phenolic, flavonoids, steroids and triterpenes were found in the leaf of AO. The freeze dried aqueous extract showed no significant different compared to BHT in in vitro antioxidant analysis when assessed using the FRAP assay. Supplementation of aqueous extract of AO (100, 200 mg/kg/day) to the hypercholesterolemic induced rabbits caused a significant decreased (p<0.05) of malondialdehyde and significant increased (p<0.05) of superoxide dismutase and catalase levels at the end of the study period compared to the groups received high cholesterol diet alone. Aqueous extract of AO possess the ability to act as an antioxidant in vitro and in vivo and also was able to increase the level of superoxide dismutase and catalase in experimental hypercholesterolemia. The presence of flavonoids in the extract could be attributed to the antioxidative effect of the plant.
 
 
 
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