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Articles by A. V. Kharagjitsingh
Total Records ( 2 ) for A. V. Kharagjitsingh
  A. V. Kharagjitsingh , K. Prinsen , H. H. P. J. Lemkes , R. R. P. De Vries , B. O. Roep and K. Buschard
  Aims  To examine a disputed association between the Lewis(ab) phenotype and Type 1 diabetes (T1D).

Methods  Lewis red blood cell phenotyping was performed for 97 T1D White patients and 100 control subjects using monoclonal antibodies. Two historical cohorts were also included as a control population.

Results  T1D patients had a lower frequency (4.1%) of Lewis(ab) blood group compared with simultaneously tested healthy control subjects (10.0%) and the historical control group (11.1%, P = 0.02). Male T1D patients showed a Lewis(ab) frequency of 8.0%, which was similar to both matched healthy male donors (9.8%) and historical (9.5%) male control subjects. Unexpectedly, none of the female T1D patients displayed Lewis(ab) phenotype, vs. 10.3% and 10.8% of female control subjects (P = 0.039 and 0.017).

Conclusions  The Lewis(ab) phenotype occurs less frequently in T1D compared with healthy control subjects with a strong female gender bias.

  A. Kaas , C. Pfleger , A. V. Kharagjitsingh , N. C. Schloot , L. Hansen , K. Buschard , B. P. C. Koeleman , B. O. Roep , H. B. Mortensen and B. Z. Alizadeh
  Aims  The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFNγ) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes.

Methods  Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFNγ gene were genotyped and serum levels of IL-10 and IFNγ were measured at 1, 6 and 12 months.

Results  IL-10 decreased (P < 0.001) by 7.7% (1 month), 10.4% (6 months) and 8.6% (12 months) per year increase in age of child, while a twofold higher C-peptide concentration at 1 month (p = 0.06), 6 months (P = 0.0003) and 12 months (P = 0.02) was associated with 9.7%, 18.6% and 9.7% lower IL-10 levels, independent of each other. IL-10 concentrations did not associate with the disease progression groups. By contrast, IFNγ concentrations differed between the four progression groups at 6 and 12 months (P = 0.02 and P = 0.01, respectively); patients with rapid progressing disease had the highest levels at both time points. Distribution of IL-10 and IFNγ genotypes was equal among patients from the progression groups.

Conclusion  IL-10 serum levels associate inversely with age and C-peptide. As age and C-peptide also associate, a triangular association is proposed. Genetic influence on IL-10 production seems to be masked by distinct disease mechanisms. Increased serum IFNγ concentrations associate with rapid disease progression. Functional genetic variants do not associate with a single progression pattern group, implying that disease processes override genetically predisposed cytokine production.

 
 
 
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