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Articles by A. Surendraraj
Total Records ( 4 ) for A. Surendraraj
  K.H.S. Farvin , A. Surendraraj and R. Anandan
  In the present study an attempt has been made to assess the cardioprotective effect of squalene on isoprenaline-induced myocardial infarction in male albino rats with respect to changes in the levels of endogenous antioxidant vitamins in heart tissue. Levels of endogenous antioxidants such as ascorbic acid, α-tocopherol and endogenous squalene content in heart tissue were determined. Significant (p<0.001) reduction was observed in the levels of ascorbic acid, α-tocopherol and endogenous squalene content in the heart tissue of isoprenaline administered rats compared to normal control rats. It is worth noting that, the prior administration of squalene at 2% level along with feed for 45 days significantly (p<0.001) reduced the isoprenaline-induced decline in the levels of these vitamins and restored the membrane bound squalene content at near normal. The results of the present study indicates that the cardioprotective effect of squalene might be ascribable to its antioxidant property thereby sharing the responsibility of these antioxidant vitamins in counteraction of free radicals generated during isoprenaline-induced oxidative stress.
  K.H.S. Farvin , A. Surendraraj and R. Anandan
  This study was aimed to evaluate the preventive role of squalene on free amino acids and lysosomal alterations in experimentally induced myocardial infarction in rats. The levels of lysosomal enzymes (β-glucuronidase, β-galactosidase, β-glucosidase, acid phosphatase and cathepsin D) in plasma and lysosomal fractions, hydroxyproline content and free amino acids in heart tissue were determined. Isoprenaline administration to rats resulted in decreased stability of the membranes which was reflected by significantly (p<0.001) lowered activity of β-glucuronidase, β-galactosidase, β-glucosidase, acid phosphatase and cathepsin D in the lysosomal fraction with a concomitant increase in plasma. Significant (p<0.001) reduction was also observed in the levels of taurine and hydroxyproline with a concomitant increase in the levels of aspartate, glutamate and arginine in the heart tissue of isoprenaline administered rats compared to normal control rats. Pretreatment with squalene at 2% level along with feed for 45 days significantly (p<0.001) prevented these alterations in free amino acids, hydroxyproline and lysosomal hydrolases and maintained the rats at near normal. Thus, the results of this present study show that squalene protects the lysosomal membrane against isoprenaline induced oxidative stress. The overall cardioprotective effect of squalene is ascribable to its ability to strengthen myocardial membrane including lysosomal membrane by its membrane stabilizing action and consequent diminution in the liberation of hydrolytic enzymes or by counteraction of free radicals by its antioxidant nature.
  R. Yathavamoorthi , A. Surendraraj and K.H. Sabeena Farvin
  Enteric bacterial population associated with farmed freshwater prawn and its environment, water quality of prawn farm and the existing association between these parameters were studied. Microbiological parameters were determined following the United States Food and Drug Administration (USFDA) methods and the physico-chemical parameters as per the standard methods of American Public Health Association (APHA). Prawn samples yielded a mean Total Plant Count (TPC) in the range of 4.57 to 6.66 log cfu g-1 and was the highest among all other samples. Prawns followed by water samples had the higher level of enteric indicator organisms. Sediment showed higher count of sulphite reducing clostridia. Emerging pathogen E. coli O157:H7 were absent in all the samples analyzed. Enterobacter (31.5%) followed by Citrobacter (13.2%) and non enteric bacteria Aeromonas (11%) were the dominant flora recovered. Escherichia, Klebsiella, Hafnia, Serratia, Salmonella and Shigella were the other opportunistic enteric bacterial pathogens detected from this system. The rearing practices such as use of cow dung as fertilizer and microbiologically contaminated feed could have influenced the enteric flora. Study on various physico-chemical parameters of pond water revealed that they were within the suitable range for the freshwater prawn culture. Correlation analysis revealed a significant positive correlation between pollution indicator parameters such as Total Organic Carbon (TOC), Biological Oxygen Demand (BOD), Chemical Oxygen Demand (COD) with that of Total Plate Count (TPC) and Total Enterobacteriaceae Count (TEC) of the pond water and prawn samples. Presence of bacteria of public health significance in the aquaculture pond envisages strict hygienic handling, processing of prawn from this system and cooking prior to consumption to ensure public health safety.
  A. Surendraraj , K.H. Sabeena Farvin , R. Yathavamoorthi and N. Thampuran
  A study was designed to investigate the enteric bacterial population associated with farmed freshwater fish and its environment, limnological quality of carp farm and the existing association between these parameters. Enteric indicator bacterial counts were determined following the United States Food and Drug Administration (USFDA) methods and the physico-chemical parameters according to the standard methods of American Public Health Association (APHA). Fish samples yielded mean microbiological counts in the range of 4.19 to 4.85 log CFU g-1, sediment in the range of 5.18±0.01 to 6.34±0.01 log CFU g-1, pond water in the range of 3.64±0.03 to 6.10±0.04 log CFU mL-1. Fish and feeder canal water showed higher count for all indicator bacterial count. Sediment showed 2 log cycle higher count of sulphite reducing clostridia. Emerging pathogen E. coli O157:H7 were absent in all the samples analyzed. Aeromonas (26.2%) followed by Enterobacter (24.6%) were the dominant flora recovered. Escherichia, Klebsiella, Serratia, Hafnia, Plesiomonas, Shigella, Salmonella, Morganella and Yersinia were the other opportunistic enteric bacterial pathogens detected from this system. The rearing practices such as natural fertilization and feeding could have influenced the enteric flora. Study on the various physico-chemical parameters of pond water revealed that they were within the suitable range for the freshwater fish culture throughout farming phase. Correlation analysis revealed a significant positive correlation between physico-chemical parameters such as total organic carbon (TOC), Biological Oxygen Demand (BOD), Chemical Oxygen Demand (COD) with that of Total Plate Count (TPC), Total Enterobacteriaceae Count (TEC), Total Coliforms (TC), Faecal Coliforms (FC) and E. coli (EC). Presence of bacteria of public health significance in the aquaculture ponds envisages a strict hygienic handling and processing of fish from the culture systems for ensuring public health safety.
 
 
 
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