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Articles by A. Soni
Total Records ( 10 ) for A. Soni
  V.K. Dwivedi , M. Chaudhary , A. Soni and S.M. Shrivastava
  Free radicals are causative factors for aminoglycoside induced renal toxicity. The aim of present study was to evaluate effect of fixed dose combination of cefepime+amikacin (Potentox) as well as ceftazidime+tobramycin (Tobracef) antibiotics on antioxidant enzymes (Super oxide dismutase, Catalase and Glutathione reductase) along with (free radical mediated damage) malonaldialdehyde levels and extracellular antioxidant enzymes (creatinine, total bilirubin and uric acid enzymes ) in kidney tissue of Mus musculus mice. Present findings showed that the activities of the antioxidant enzymes were significantly lowered along with increase in MDA (malonaldialdehyde) levels and extracellular antioxidants after single treatment of aminoglycosides (amikacin and tobramycin) as compared to control group. A significant improvement in antioxidant enzymes along with significant decrease in creatinine, total bilirubin, uric acid and malonaldialdehyde (MDA) levels were observed in fixed dose combination of cefepime plus amikacin as well as ceftazidime+tobramycin treated groups compared to amikacin and tobramycin alone treated group. These results indicate that a fixed dose combination of cephalosporins with aminoglycosides using chemical vector mediated technology acts as an antioxidant and prevents nephrotoxicity induced by aminoglycosides.
  A. Ahmad , M. Chaudhary , A. Soni , A. Payasi and V.K. Dwivedi
  In the present study, the researchers have tried to determine the toxicity of a novel fixed dose combination of ofloxacin plus ornidazole (mebatic) vs. ofloxacin, ornidazole and metronidazole alone drugs in the plasma of Wister rats. Total thirty Wister rats were randomly selected and divided into five groups of six rats each. Group I was control normal saline (0.9% NaCl) treated group where as rest of four groups were treated with respective drugs. The drugs were given to animals intravenously for 24 days and blood samples were collected on 12th and 24th day after treatment for the measurement of biochemical parameters. Present results showed that there was insignificant increase in hemoglobin level on 12th and 24th day in mebatic treated group as compared with other treated groups. The levels of uric acid, alkaline phosphatase, creatinine, bilirubin and hepatic enzymes were found to be lowered but insignificant in mebatic treated group on 12th and 24th day treatment in comparison to ofloxacin, ornidazole as well as metronidazole alone treated groups. These levels were found to be almost near to normal level in mebatic treated group. When ofloxacin, ornidazole as well as metronidazole alone treated groups were compared to control group, these hepatic and renal parameters were significantly increased except in mebatic treated group. The level of free radical mediated damage was also significantly decreased in mebatic treated group in comparison to other treated groups. Therefore, these findings concluded that mebatic drug is less toxic and most effective than ofloxacin, ornidazole and metronidazole alone which improved hepatic and renal enzymes and free radical mediated damage.
  A. Soni , V.K. Dwivedi , M. Chaudhary , S.M. Shrivastava and V. Naithani
  This study was designed to determine the efficacy of ampucare against oxidative organ damage distant from the original burn wound. Under brief ketamine anesthesia, the shaved dorsum of the rats was exposed to 80°C (burn group) by hot wax for 5 min. The rats were fed standard pelleted diet and water ad libitum. The test room was air conditioned with temperature 23±2°C, humidity 65±5% and with artificial fluorescent light (10-14 h of light and dark), respectively. Rats were left for 24 h after burn injury and blood were taken for the determination of superoxide dismutase (SOD), catalase (CAT) activity, malonaldialdehyde (MDA), myeloperoxidase (MPO), xanthine oxidase (XO) and total protein level. Present findings showed that activities of antioxidant enzymes were significantly decreased along with increased level of MDA, MPO and XO in untreated group at 7th and 14th day of study. Similarly, the level of total protein was also found to be significantly lowered in untreated group at 7th and 14th day. These antioxidant enzymes (SOD, Catalase) along with MDA, MPO and XO were improved and come back to normal level. In conclusion, ampucare scavenges free oxygen radicals, decreases MDA or MPO level in blood and increase the antioxidant enzyme activity by preventing its inhibition. Considering our results, ampucare would be a beneficial for humans who suffer from thermal injury.
  V.K. Dwivedi , A. Soni , A. Payasi , A. Ahmad , Shambhu P. Singh and M. Chaudhary
  The aim of present study was to evaluate the effect of levofloxacin and potentox drugs in osteomyelitis -induced rat model. Staphylococcus aureus 100 μL (1x106 CFU mL-1) was inoculated into the proximal metaphysis of the tibia for induction of osteomyelitis. Body weight and temperature of osteomyelitis-induced rats were monitored every 4th day for three weeks before and after treatment with levofloxacin and potentox. Levofloxacin and potentox were given to animals by intravenously for 21 days. To determine the biochemical parameters (Protein, CRP, Na, Phosphorus, Calcium levels), hepatic enzymes as well as renal function test along with cytokines and malondialdehyde (MDA), myeloperoxidase (MPO) levels in the serum of osteomyelitis-induced untreated and treated groups. Our results showed that the levels of biochemical parameters as well as renal function test along with malondialdehyde, myeloperoxidase levels were significantly altered in the untreated group as compared to levofloxacin and potentox treated groups. When levofloxacin treated group was compared to potentox-treated group, the renal function test and levels of biochemical parameters along with malondialdehyde, myeloperoxidase levels and cytokines were significantly improved in the serum of potentox-treated group. The hepatic enzyme activity was found to be higher in levofloxacin treated group in comparison to potentox-treated group. These study concluded that potentox act as an antioxidant by improving free radical mediated damage and prevents osteomyelitis infection and hepatoxicity in comparison to levofloxacin, caused by Staphylococcus aureus microorganism.
  V.K. Dwivedi , M. Chaudhary , A. Soni , J. Yadav , A. Tariq , M.R. Siddiqui , A. Ahmad and P.S. Negi
  The present study was to investigate the comparative efficacy of ceftriaxone and a fixed dose combination of ceftriaxone plus sulbactam along with VRP1034 (Sulbactomax) in cerebrospinal fluid (CSF) of meningitis induced rat model. Eighteen rats were divided into three groups of six rats each. Meningitis were induced by MRSA strain (log 106 cfu mL-1). Group I was infected group; whereas group II and III were ceftriaxone and sulbactomax treated groups. Drugs were analyzed in CSF by high performance liquid chromatography. Some biochemical parameters were studied in infected and treated groups. Present results showed that the mean level of ceftriaxone drug concentration was increased significantly in sulbactomax treated group in comparison to ceftriaxone alone treated group. Glucose level was increased in sulbactomax treated group as compared to ceftriaxone alone treated group. The levels of protein, calcium and phosphorus were significantly lowered in both treated group as compared to infected group. These biochemical parameters were decreased along with increased glucose level in sulbactomax treated group in comparison to ceftriaxone alone treated group. Present findings concluded that sulbactomax enhanced the penetration rate in CSF than ceftriaxone alone due to VRP1034. It plays a therapeutic role in crossing blood brain barrier and helps in prevention of bacterial meningitis infection.
  A. Soni , V.K. Dwivedi and M. Chaudhary
  The study was planned to monitor antioxidant and extracellular parameters on different days of interval in blood of infected and treated groups of mice during abdominal infection by treatment of ceftriaxone plus vancomycin (vancoplus). Fifty-four young Mus musculus mice were divided into three groups as follows: control group (n = 6), infected group (n = 24) and treated with CV group (n = 24). Intraperitonial injection of Escherichia coli (1x106cfu) was given for intra abdominal infection. FDC of CV was administered intravenously in the dosage of 42.8 mg kg-1 body twice daily for 7 days. The activities of antioxidant enzymes such as superoxide dismutase and catalase as well as the concentration of malonaldialdehyde, as an indicator of lipid peroxidation were measured to evaluate oxidative stress in blood. A significant increased in malonaldialdehyde, creatinine and uric acid levels (p<0.001) were found in infected group when compared to control and treated groups. Superoxide dismutase (p<0.01) and catalase (p<0.001) activities were found to be decreased in infected group as compared to control and treated groups. It can be concluded that ceftriaxone-vancomycin shows broad spectrum against E. coli and prevent oxidative damage of tissue injury by reducing reactive oxygen species. These finding suggests that, based on their anti-oxidative capability, these agents could provide benefit in anti-infective therapy and reduces safely relief against intra-abdominal infection.
  A. Soni , V.K. Dwivedi , M. Chaudhary and S.M. Shrivastava
  The aim of this study was to compare the efficacy of ceftriaxone, vancomycin and its fixed dose combination of ceftriaxone plus vancomycin (Vancoplus) for the treatment of meningitis induced by methicillin-resistant Staphylococcus aureus (MRSA) in rat model. The MRSA strain ATCC 43300 was used to induce meningitis in rat model. The rats were fed standard pelleted diet and water ad libitum. Thirty rats were divided into five groups containing six rats in each group. The vancomycin group received 14.2 mg kg-1 b.wt./day, the ceftriaxone group received 28.57 mg kg-1 b.wt./day, the vancoplus group received 42.8 mg kg-1 b.w./day, control and infected group received normal saline. Present findings showed that activities of antioxidant enzymes such as superoxide dismutase and catalase were significantly increased (p<0.001) along with decreased (p<0.001) in lipid peroxidation (malondialdehyde) level in vancoplus treated group as compared to ceftriaxone and vancomycin. The level of adenylate kinase and xanthine oxidase enzymes also become lowered in vancoplus treated group as compared to ceftriaxone and vancomycin. The levels of total protein, calcium and phosphorus were also increased significantly (p<0.001) along with decreased (p<0.001) in glucose level in cerebral spinal fluid of infected group as compared to control group. After treatment with vancoplus, levels of total protein, calcium and phosphorous become reduced along with raised in glucose level as compared to ceftriaxone and vancomycin group. These findings indicate that vancoplus is more effective than ceftriaxone and vancomycin alone for improvement of oxidant and antioxidant levels, it also crosses the blood brain barrier more faster than ceftriaxone and vancomycin alone and cure bacterial meningitis.
  A. Soni , A. Kumar , V. Nath and A. Niveden
  : Genetic diversity of the Monoceious thalloid liverwort Plagiochasma appendiculatum was investigated by Rapid Amplified Polymorphic DNA (RAPD) analysis. The species is explained and demonstrated with its genetic diversity on the basis of morphological variations. Samples were collected from different parts of India growing on different habitat at variable altitude. After the study of its morphology, it has been observed that the population of this taxon shows significant variation in plant size, shape, colour, ventral scales, appendages of scales, rhizoids, position of male and female receptacles etc. Based on such morphological variations, we have used the RAPD marker to estimate the genetic diversity within and between the populations. Approximately 75% of the variations have been observed within and between genotypes of P. appendiculatum as revealed with both phenotypic and genotypic data. The RAPD markers are being used increasingly to analyze the phylogenetic relationship among the liverworts to give the exact framework of taxonomic identification of naturally occurring liverwort P. appendiculatum.
  A. Soni , M. Chaudhary , A. Tamta , R. Sehgal , S.M. Shrivastava and V.K. Dwivedi
  This study investigated to comapre the efficacy of ofloxacin, ornidazole and mebatic (Fixed dose combination ornidazole plus ofloxacin). Various parameters related to blood, liver and kidney were studied in the monotherapy as well as in the combination therapy. To further explore the mechanisms of better efficacy showed by combination, antioxidant defense status was also explored. The mice were fed standard pelleted diet and water ad libitum. The test room was air conditioned with temperature 22±2°C, humidity 60.5% and with artificial fluorescent light 10-12 h of light and dark, respectively. Twenty four mice were divided into four groups containing six mice in each group. Ofloxacin treated group recieved 3.3 mg kg-1 b.wt. day-1, ornidazole treated group received 8.3 mg kg-1 b.wt. day-1 and mebatic treated group received 11.6 mg kg-1 b.wt. day-1 whereas control group received normal saline. The findings of present study suggested that the combination formulation showed no signs of toxicity when tested for liver and kidney related parameters. The combination formulation also attenuated the oxidative stress and also preserved the antioxidant enzyme levels (catalase and superoxide dismutase) in treated group. From the results of our study it can be concluded that the combination was safe as compared to treatment of the individual agents. It was also infer that the normalized antioxidant defense status might be responsible for decrease in hepatotoxicity and nephrotoxicity in the combination group as compared with monotherapies using either agent.
  A. Soni , M. Chaudhary , V.K. Dwivedi , S.M. Shrivastava and R. Sehgal
  The aim of the present study was to evaluate the effect of various treatment of glycerol, mannitol, neurotol and neurotol plus on xanthine oxidase, adenylate kinase activities and MDA levels in alcohol induced ischemic rat model. Twenty Wistar rats (weighing 100- 200 g) were divided into four groups, glycerol treated group (20%), mannitol treated group (10%), fixed dose combination of glycerol (10%)+ mannitol (20%) (Neurotol) treated group and neurotol plus treated group (glycerol (10%)+mannitol (10%)). A significant decrease in xanthine oxidase activity, adenylate kinase activity and MDA levels were observed on treatments but decrease was maximum in neurotol plus treated groups suggesting that it has better free radical scavenging activity than glycerol, mannitol and neurotol.
 
 
 
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