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Articles by A. Shukla
Total Records ( 3 ) for A. Shukla
  P. Bigoniya , A. Shukla and C.S. Singh
  The effect of picroliv isolated from Picrorrhiza kurroa was evaluated at different dose ranges to establish its ED50 against carbon tetrachloride (CCl4) induced hepatotoxicity. The CCl4 was given orally (1 mL kg-1 b.wt.) in liquid paraffin (1:1). Picroliv at different doses and silymarin (20 mg kg-1 b.wt.) standard were administered orally for 14 days. Body weight, biochemical parameters like Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT) and Alkaline Phosphatase (ALP) were estimated. Hepatic microsomal drug metabolizing enzyme functional integrity was accessed by in vitro bromosulphalein (BSP) uptake test of liver slices and thiopental (40 mg kg-1 b.wt.) induced sleeping time. The results showed dose related hepatoprotective efficacy of picroliv. The ED50 values for effectiveness of liver enzyme metabolizing activity on BSP uptake test and sleeping time were 11.94 and 17.49 mg kg-1 b.wt., respectively.
  N. Mishra , N.S. Gill , A. Mishra , S. Mishra , A. Shukla and A. Upadhayay
  Medicinal plants have been traditionally used for the treatment and prevention of peptic ulcer. The present study was designed to investigate antioxidant and antiulcer potential of methanolic fruit extract of Prunus domestica. Antioxidant activity was measured by 1,1-diphenyl-2-picrylhydrazyl and hydrogen peroxide free radical scavenging method. The extract showed maximum scavenging activity i.e., 82.12±0.654 and 79.43±0.876 at 200 μg mL-1. Further the extract was evaluated for its anti-ulcerogenic activity by pyloric ligation model. The extract showed significant inhibition of ulcer i.e., 70.58% at 200 mg kg-1. The present study concludes that Prunus domestica fruit posses potent antioxidant and anti-ulcerogenic effect.
  A. Shukla , P. Bigoniya and B. Srivastava
  Lepidium sativum Linn. (Family Cruciferae) popularly known as Garden cress has been used in traditional and folklore medicine for the treatment of bronchial asthma, diabetes, local and rheumatic pain. The present study aimed at investigation of antidiabetic efficacy of L. sativum Seed Total Alkaloid (LSTA). The major components of this alkaloid fraction are lepidine and semilepidine, a rare group of imidazole alkaloid. Antidiabetic profile of LSTA (50, 150 and 250 mg kg-1, i.p.) was assessed on alloxan induced diabetic rats upon 21 days continuous treatment. Biochemical parameters viz., glucose, total cholesterol, triglycerides, low density lipoprotein, high density lipoprotein, urea and creatinine were determined along with b.wt. and relative organ weight. LTSA at 250 mg kg-1 showed 1.94% b.wt. gain on 21th day relative to 6.14 and 8.94% of control and diabetic group. LSTA at 250 mg kg-1 dose significantly (p<0.001) suppressed blood glucose, cholesterol, triglyceride and urea level in diabetic rats. The results revealed that LSTA at dose 250 mg kg-1 showed potent hypoglycemic activity. The L. sativum alkaloid have potential antidiabetic effect against alloxan-induced diabetes may be through reducing oxidative damage and modulating antioxidant enzymes. The possible mechanism by which LSTA brings about its anti-hyperglycaemic action may be by potentiation of pancreatic secretion of insulin from the remaining islet β cells.
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