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Articles by A. Shabani
Total Records ( 5 ) for A. Shabani
  P. Ghadam , A. Abadi , A. Asadzadeh , N. Safari , A. Shabani and M. Sharifian
  In this study, we found that allelic polymorphism in Hp gene acts as a major determinant of susceptibility for the development of diabetic cardiovascular complications. We studied this gene in 122 Iranian diabetic cardiovascular patients. The results showed that distribution of the Hp phenotypes were found to be in Hardy-Weinberg equilibrium. By using the chi square test we determined the association between Hp allele and diabetic cardiovascular diseases (χ2 = 52.98 p<0.001) and this finding was independent of gender (χ2 = 0.39 p>0.05). The chance of having allele two in diabetic patients with cardiovascular disease was 22.31 (95% CI, 6.18 to 80.5) times more than those with allele one (p<0.0001).
  F. Ghazi , M. Firoozrai , B. Dabirmanesh and A. Shabani
  Angiotensin-Converting Enzyme (ACE) is a dipeptidyl carboxypeptidase (EC: that catalyzes the conversion of angiotensin I to the potent vasoconstrictor angiotensin II. Angiotesin II is responsible for an increase in blood pressure and maintenance of hypertension through the stimulation of oxidative stress. The relationship between Coronary Artery Disease (CAD), Angiotensin-Converting Enzyme (ACE) activity, ascorbic acid and serum antioxidant status in patients with coronary artery disease. A group of 65 patients with angiographically defined Coronary Artery Disease (CAD) and 60 normal control subjects were examined. The activity of Angiotensin-Converting Enzyme (ACE) was determined by the reversed-phase High Performance Liquid Chromatography (HPLC) to separate and quantify Hippuryl-Histidyl-Leucin (HHL) and Hippuric Acid (HA). Ferric Reducing Ability of Plasma (FRAP Assay) as a measure of antioxidant power was used. Serum ascorbic acid concentration was determined photometrically. The results demonstrated significant differences in ACE activity, antioxidant and ascorbic acid between CAD cases and normal controls. Increased levels of ACE activity in serum have been related to coronary artery disease. Serum ascorbic acid concentration (25.6±3.8 mg dL-1) and total antioxidant capacity (475.5±18.51 μM L-1) were significantly (p<0.05) decreased in CAD patients compared with controls.
  A. Shabani , B. Dastar , M. Khomeiri , B. Shabanpour and S. Hassani
  This experiment was conducted to evaluate the efficiency of nanozeolite against aflatoxicosis in broiler chickens. For this purpose, 336 male Ross 308 day old broiler chickens were allocated to 6 dietary treatments, including a control corn-soybean meal diet without Aflatoxin (AF) and Nanozeolite (NZ) and five diets contaminated with 500 ppb AF and containing 1 of 5 levels of zero, 0.25, 0.5, 0.75 and 1% Nanozeolite (AFNZ0, AFNZ0.25, AFNZ0.5, AFNZ0.75 and AFNZ1, respectively). Data were analyzed as a completely randomized design with 4 replications and 14 birds per repetition. The results showed that the lowest weight gain and feed intake and the highest feed conversion ratio were related to diet containing 500 ppb AF without NZ (AFNZ0 diet). The birds were fed AFNZ0 showed lower weight gain in 2nd, 3rd and 4th weeks in comparison with control diet (p<0.05). AF led to reduce feed intake and increase feed conversion ratio in 3rd week (p<0.05). No significant differences observed between control diet and contaminated diets containing different levels of NZ for body weight gain, feed intake and feed conversion ratio at all weeks. Serum total protein, cholesterol and triglyceride concentrations were significantly lower in AFNZ0 compared to control diet (p<0.05). There was no significant difference between dietary treatments for serum albumin. These findings confirm that at least 0.25% NZ is sufficient to reduce the toxicity of AF in broiler chickens.
  S. Yeganeh , B. Shabanpour , H. Hosseini , M.R. Imanpour and A. Shabani
  In this research, the seasonal variation in the chemical composition and fatty acid profile of fillets from wild common carp were assessed. The protein, lipid and moisture content as well as the fatty acid profile were determined. The results showed that the lipid and protein content in wild carp samples decreased from Summer to Spring and the moisture content of fillets increased from Summer to Spring. Monounsaturated Fatty Acids (MUFA) in carp were found to be higher than levels of Saturated Fatty Acids (SFA) and Polyunsaturated Fatty Acids (PUFA) in all seasons. The PUFA content of fillets was found to be higher than that of SFA in Winter and Spring. Palmitic acid was the major SFA (12.99-16.18%) in all seasons. Oleic acid was identified as the major MUFA (19.05-25.11%). Docosahexaneoic Acid (DHA) was the major PUFA (5.98-11.61%) in all seasons. The maximum concentration of DHA was found in Autumn and Winter but the Eicosapentaneoic Acid (EPA) concentration did not fluctuate in different seasons. The maximum concentrations of lipids and protein were found in Summer. Poly-unsaturated fatty acids increased in the cold season.
  M. Islami , A. Shabani , M. Saifi-Abolhassan , Sh. Sepehr , M.R. Soudi and S.Z. Mossavi-Nejad

Purification and characterization of alcohol dehydrogenase (ADH) from Gluconobacter suboxydans was done in order to biotechnological and industrial application. Solubilization of enzyme from bacterial membrane fraction by Triton X-100 and subsequent fractionation on DEAE-Sephadex A-50 and Hydroxyapatite was successful in enzyme purification. Enzyme assay reaction mixture contained potassium ferricyanide 0.1 M, McIlvaine buffer 0.1 M (pH 5.5), Triton X-100 10%, ethanol 1 M and enzyme solution. The purified ADH Optimum pH activity was 5.5. The enzyme was in maximum stability in pH 5.8. The substrate specificity of the enzyme was determined using the same enzyme assay method as described above, except that various substrates (100 mM) were used instead of ethanol. The relative activity of the ADH for ethanol was higher than the others. The effects of metal ions and inhibitors on the activity of the enzyme were examined by measuring the activity using the same assay method as described above. Activity of purified enzyme was increased in the presence of Ca+2 and was decreased in presence the of ethylenediamine tetra acetic acid (EDTA). Because the proper structure and function of the enzyme is related to structural Ca+2 and EDTA can chelate Ca+2. An apparent Michaelis constant for ethanol were examined to be 1.7x10-3 M for ethanol as substrate.

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