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Articles by A. Semalty
Total Records ( 3 ) for A. Semalty
  M. Semalty , A. Semalty , Geeta P. Joshi and M.S.M. Rawat
  The present study deals with the assessment of hair growth potential of three plants, Semecarpus anacardium, Trigonella foenumgraecum and Trigonella corniculata. Petroleum ether and ethanolic extracts of all the plants were prepared. Aloe vera gel (prepared with fresh Aloe vera leaves) based herbal formulations were prepared with both types of extracts of each plant. The formulations were subjected to characterization of pH, texture, odour and toxicity studies. Hair growth activity of the formulations was studied in comparison of 2% minoxidil solution (standard) in albino rats for 30 days. It was concluded that T. foenumgraecum showed the best hair growth activity. Formulation containing T. foenumgraecum petroleum ether extract showed the minimum time to initiate (5 days) as well as to complete the hair growth (18 days) at denuded surfaces. Formulation with T. foenumgraecum ethanolic extract showed the best hair lengthening properties as compared to others. The study concluded that even the short-term treatment with these herbal formulations is effective in significant hair growth promotion.
  P. Kumar , A. Semalty , S.R. Mir , M. Ali and S. Amin
  The plant Pongamia pinnata (Linn.) Pierre of family Leguminosae sub-family Papilioanaceae was evaluated for its hypoglycemic and hypolipidemic activity in streptozotocin induced diabetic rats. A new difuranoflavonone Compound PP (named Pongamiaflavonol), isolated from methanlolic extract of P. pinnata pods by column chromatography, was also studied for the activity. It was observed that after 14 days of treatment blood glucose level was reduced by 66.34, 54.82, 63.62 and 67.48 % with Std. Glibenclamiade 3 mg kg-1), P. pinnata pods (300 mg kg-1), P. pinnata flowers (300 mg kg-1) and PP (100 mg kg-1), respectively. The lipid profile was also studied and was found to be normalized significantly by both the flowers and pods extracts of P. pinnata and compound PP.
  A. Semalty , M. Semalty , P. Kumar , S.R. Mir , M. Ali and S. Amin
  Pongamia pinnata (family Papilionaceae) has been used for bronchitis, whooping cough, rheumatic joints and quench dipsia in diabetes. This study deals with the isolation of a new hypoglycemic phytoconstituent from P. pinnata pods. The hypoglycemic activity of the isolated phytoconstituent was evaluated in comparison of the methanolic extract of the pods.. Methanolic extract of P. pinnata pods was fractionated by column chromatography and the isolated compounds were identified by spectral analysis. A new compound named Pongamiaflavonylflavonol was isolated from chloroform: methanol (97:3) eluant. This new isolated compound was studied for hypoglycemic activity in streptozotocin induced diabetic rats. Methanolic extract of P. pinnata pods and pongamiaflavonylflavonol showed significant hypoglycemic activity in streptozotocin-induced hyperglycemic rats after oral administration. At the end of 6 h the new compound showed 12.15% reduction in blood glucose level in comparison of extract (11.36%) against the standard (16.93%). It can be concluded that the novel Pongamiaflavonylflavonol isolated from P. pinnata pods may be useful as oral hypoglycemic therapeutic agent. This may serve as a lead compound for development of more potent drugs for clinical use in diabetes.
 
 
 
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