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Articles by A. Sarwar
Total Records ( 3 ) for A. Sarwar
  A. Sarwar , M.S. Rahman , T.B. Huq , K. Biswas , M.I. Hussain , J.F. Chaity , T. Begum , Md. E. Haque , A. Islam and Mst. M. Begum
  Background and Objective: To compare the prevalence of acute vomiting between patients receiving cisplatin as monotherapy or cisplatin in a combination regimen. Materials and Methods: The study was conducted at Delta Hospital Dhaka on a total of 70 patients (44 male and 26 female). The patients received either cisplatin alone or cisplatin with the following chemotherapeutic agents-docetaxel and 5 fluorouracil, docetaxel, etoposide, doxorubicin and capecitabine. The study was conducted in patients receiving chemotherapy for a total of the first 3 cycles. The patients were told to record the number of episodes of vomiting they experienced during the first 24 h after chemotherapy at each cycle. All 70 patients received prechemotherapy antiemetics a combination of 5HT3 receptor antagonist (ondansetron or palanosetron) and dexamethasone prior to chemotherapy. Results: In patients receiving the combination chemotherapy of cisplatin+docetaxel+5 FU experienced the lowest incidence of acute vomiting and cisplatin+capecitabine receiving patients experienced highest incidence of acute vomiting. All the other combination therapy resulted in emesis comparatively similar to that of cisplatin. In all the regimens except for cisplatin+etoposide the percentage of patients experiencing acute vomiting reduced along with progressive cycles. Conclusion: When cisplatin is given in combination regimen except for the combination regimen of cisplatin+capecitabine there is no significant increase in emesis between patients receiving cisplatin alone or in combination therapy.
  A. Tabassum , R.R. Saha , M.S. Rahman , M.A. Nure , R. Karim , A.H.M.R. Imon , M. Maniruzzaman , A.K.L. Kabir , A. Islam , J.F. Chaity , B.C. Adhikary , A. Sarwar , T.B. Huq and Mst. M. Begum
  Background and Objective: Pain management has been an area of a great deal of attention for pharmacists for many years. In this study, we report a study which is designed to investigate how a combination of existing effective drugs performs for the relief of pain management. Materials and Methods: A combined solid dosage containing paracetamol (500 mg) and ibuprofen (150 mg) is developed and tested under an observational analytical study. The performance of this combined oral solid dosage named maxigesic tablet in order to reduce pain is investigated on the basis of European patent specification. This assay is carried out by employing HPLC system with UV detection at 222 nm. Results: The results show the presence of active components to the tune of 112.12% for paracetamol and 101.86% for ibuprofen. The formulated solid dosage is further subjected to separate groups of artificially pain induced mice for a comparative study and it shows more efficacy than single analgesic used in pain management. We observe that the respective potencies for paracetamol and ibuprofenare 98.57 and 102.90%. Conclusion: The characterization of both granules and tablets of newly developed formulation demonstrates significant improvement in results of analytical test that not only met the standard specification, but they also reveal that the combined dosage will improve the product quality, efficacy and patient safety in the long run. This trial also shows a significant difference in the percentage of pain inhibition between the two sets of formulations (single and combination of them).
  A hydroponics experiment was conducted to evaluate the role of potassium (K) and silicon (Si) in mitigating the deleterious effects of NaCl on sugarcane genotypes differing in salt tolerance. Two salt-sensitive (CPF 243 and SPF 213) and two salt-tolerant (HSF 240 and CP 77-400) sugarcane genotypes were grown for six weeks in ½ strength Johnson's nutrient solution. The nutrient solution was salinized by two NaCl levels (0 and 100 mmol L−1 NaCl) and supplied with two levels of K (0 and 3 mmol L−1) and Si (0 and 2 mmol L−1). Applied NaCl enhanced Na+ concentration in plant tissues and significantly (P ≤ 0.05) reduced shoot and root dry matter in four sugarcane genotypes. However, the magnitude of reduction was much greater in salt-sensitive genotypes than salt-tolerant genotypes. The salts interfered with the absorption of K+ and Ca2+ and significantly (P ≤ 0.05) decreased their uptake in sugarcane genotypes. Addition of K and Si either alone or in combination significantly (P ≤ 0.05) inhibited the uptake and transport of Na+ from roots to shoots and improved dry matter yields under NaCl conditions. Potassium uptake, K+/Na+ ratios, and Ca2+ and Si uptake were also significantly (P ≤ 0.05) increased by the addition of K and/or Si to the root medium. In this study, K and Si-enhanced salt tolerance in sugarcane genotypes was ascribed to decreased Na+ concentration and increased K+ with a resultant improvement in K+/Na+ ratio, which is a good indicator to assess plant tolerance to salt stress. However, further verification of these results is warranted under field conditions.
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