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Articles by A. Saifi
Total Records ( 4 ) for A. Saifi
  T. Dadgar , M. Asmar , A. Saifi , M. Mazandarani , H. Bayat , A. Moradi , M. Bazueri and E. Ghaemi
  Bacterial resistance to antibiotics is a serious global problem and includes strains of beta-lactam-resistant Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Novel antimicrobials and/or new approaches to combat the problem are urgently needed. The aim of this study was to investigate the antimicrobial activity of alcoholic and aqueous extract of 23 medical plants species of Golestan province on clinical and standard stains of MRSA and MSSA. Twenty three medicinal plants were collected from their natural habitat in Golestan province in north of Iran. Their ethanolic and aqueous extract obtained by percolation methods. Antibacterial effects were assessed by disk diffusion method and the Minimum Inhibitory Concentration (MIC) of the extracts was determined by the micro broth dilution against 14 clinical and standard strains of methicillin resistant and sensitive of Staphylococcus aureus. The ethanolic and aqueous extract of 8, plants showed best anti staphylococcal effect, respectively. The ethanolic extract of Artemisia, herbaalba, Nigella sativa, Punica granatum, possed the most outstanding in vitro antibacterial activity which the maximum inhibition zone was 22.4-18 mm, respectively and the lowest MIC values was measured in Punica granatum, as 0.01 mg mL-1 against MRSA The results showed that ethanolic extract had better antibacterial effect than aqueous extract and anti staphylococcal activity of Ethanolic extract of plants against MRSA was better than MSSA strains. Ethanolic and aqueous extract of Punica granatum had the best antibacterial activity against the tested microorganisms. The result obtained from these plants might be considered sufficient for further studies.
  A.R. Mansourian , A. Saifi , M.A. Vakili , A. Marjani , E. Ghaemi , A. Moradi and A.R. Ahmadi
  This study was carried out to evaluate the pattern of antibiotics prescribed by either General Physician or specialist, mostly practiced medicine in the private sectors, in Gorgan, Located in south-east Caspian sea in the northern Iran. This research was a prospective study, using a pharmacist administrated questionnaires to record the prescribed antibiotics. The findings indicated amoxicillin, cephalexin, penicillin, with 31.4, 21 and 17.4% are among the most widely prescribed antibiotics, respectively. ENT specialist prescribed the highest rate of antibiotics (24.1%), although as whole General physicians are among high antibiotics prescribing doctors, with such rate of antibiotics prescription, an educational program, among the community health centers, especially for young physicians on the need for antibiotics therapy and risk factors associated with increase rate of antibiotic resistant organism are suggested.
  A.R. Mansourian , E.O. Ghaemi , A.R. Ahmadi , A. Marjani , A. Moradi and A. Saifi
  The purpose of this study was to describe the distribution of serum prostate specific antigen (PSA) and to determine age-specific reference range in a population of Persian men. Venous blood samples were taken from 287 men, from Gorgan located in the North of Iran, South-East of Caspian Sea, aged 15≥80 year. The serum PSA levels was measured using Enzyme-linked Immunosorbant-Assay (ELISA) technique and age-specific range for PSA level was determined. The serum prostate-specific antigen level for six age group of 15-40 years, 41-50 years, 51-60 years, 61-70 years, 71-80 years and >80 years were mainly in the range of 0-2.5 ng mL-1, for 76.6%, 2.6-4 ng mL-1 for 9.1% and as whole 85.7% of all men in this study had ≤4 ng mL-1, 8.7 and 5.6% all men of six age group had PSA level of 4.1-10 ng mL-1 and >10 ng mL-1, respectively. The findings of present study indicated that a large proportion (76.6%) men in this region have a lower PSA level of 0-2.5 ng mL-1 and only 9.1% of men have PSA level of 2.6-4 ng mL-1. It is therefore concluded that acceptable reference range of 0-4 ng mL-1 for PSA level require further reassessment.
  A.R. Mansourian , A.R. Ahmadi , A. Saifi and S. Bakhshandehnosrat
  Hypothyroidism is associated with mental and growth abnormality in children. The aim of this study was to determine the reference range of thyroid stimulating hormone (TSH). Thyroxin (T4) and triodothyronine (T3) of children in Northern Iran. The sample population for this study consists of subjects of 4 age groups up to 21 years. The subjects were selected randomly from people referred to Danesh Medical Diagnostic Laboratory in Gorgan Northern Iran. Thyroid hormone level were investigated with Radio immunoassay. The mean concentration for T4, T3, TSH for the sample population of 4 groups were as follow (113.5, 107.4, 102.9, 99.2 nmol L-1), (1.9, 1.7, 1.9, 1.6 nmol L-1) and (2.1, 3.5, 2.9, 2.7 mIu L-1). The mean value of T3, TSH were higher for females but the mean value of T4 was slightly higher in males. The findings of this investigation indicated that there is an inverse age correlation in particular for T4 in all age groups. On the bases of the results from this study, we conclude that reference range, in all age groups and lower, upper limits of our reference range are not universally similar; therefore determination of reference range in each region is a critical need for clinical practice.
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