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Articles by A. Rodriguez
Total Records ( 3 ) for A. Rodriguez
  A. C Naj , M West , S. S Rich , W Post , W. H. L Kao , B. A Wasserman , D. M Herrington and A. Rodriguez

Background— Little is known about the association of scavenger receptor class B type I (SCARB1) single-nucleotide polymorphisms (SNPs) and subclinical atherosclerosis, particularly in subjects of different racial/ethnic backgrounds. We examined this relationship in the Multi-Ethnic Study of Atherosclerosis.

Methods and Results— Forty-three SCARB1-tagging SNPs were genotyped. Baseline examinations included fasting lipids and subclinical atherosclerosis phenotypes (coronary artery calcification, common carotid intimal-medial artery thickness [CCIMT], and internal carotid intimal-medial artery thickness). Examining SNP associations with different subclinical atherosclerosis phenotypes across multiple racial/ethnic groups with adjustment for multiple covariates, we found that the C allele of SNP rs10846744 was associated with higher CCIMT in African American (P=0.03), Chinese (P=0.02), European American (P=0.05), and Hispanic participants (P=0.03) and was strongly associated in pooled analyses (P=0.0002). The results also showed that the association of this SNP with CCIMT was independent of lipids and other well-established cardiovascular risk factors. Stratifying by sex, there seemed to be a strong association of rs10846744 with CCIMT in women, but no genotype-sex interactions were observed.

Conclusions— Variation in SCARB1 at rs10846744 was significantly associated with CCIMT across racial/ethnic groups in Multi-Ethnic Study of Atherosclerosis.

  A. Rodriguez , A. Calle , L. Vazquez , F. Chacon , P. Polavieja and J. Reviriego
  Aims  To assess blood glucose control and quality of health care provided to non-insulin-treated patients with Type 2 diabetes mellitus in routine clinical practice in Spain.

Methods  In this observational, retrospective, cross-sectional study, patients were grouped as either having good or suboptimal blood glucose control according to International Diabetes Federation or American Diabetes Association HbA1c goals. Clinical and socio-demographic data and compliance with the main standard level of care recommendations of the International Diabetes Federation were recorded during a routine visit. Correlates of glucose control were analysed by logistic regression.

Results  Many patients were grouped as having suboptimal control under International Diabetes Federation (61.9%) or American Diabetes Association (45.0%) criteria. The mean number of accomplished International Diabetes Federation recommendations (7.3 out of 11) was higher for endocrinologists (than for internists or primary care physicians), and significantly more patients under their care were in the good glucose control group (than with primary care physicians). More recommendations were associated with blood glucose control using International Diabetes Federation than American Diabetes Association criteria, demanding higher quality of health care for achieving stricter goals. Some recommendations were poorly observed, particularly those concerning patients' education on diabetes, the prompt prescription of effective treatments and monitoring of complications. Diabetes complications were associated with being in the suboptimal control group. Patients' education on diabetes and HbA1c monitoring were associated with being in the good control group.

Conclusions  These results demonstrate the need for improvement in the management of patients with non-insulin-treated Type 2 diabetes in actual clinical practice in Spain. Such improvement would entail a stricter adherence to International Diabetes Federation recommendations.

  M. Mellado , J.R. Arevalo , A. De Santiago , E.A. Lozano and A. Rodriguez
  An experiment was conducted to examine how Trenbolone Acetate (TBA, 33 mg)/estradiol-17β (E2, 5 mg) implant affect diet selection of pluriparous mixed-breed goats (n = 10 per treatment) grazing in a highly degraded microphyll desert scrub of northern Mexico. Diets of goats were examined using microhistological fecal analysis during the peack growth of forages (August-October). TBA-E2 caused a 48% increase (p<0.01) in daily weight gain of goats. Woody plants were the main component of goat diet with no differences between implanted and nonimplanted goats (64±7 vs. 65±8% across months of study). Differences between diets of implanted and nonimplanted goats were mainly an increase (p<0.01) in Acacia farnesiana, Agave lechuguilla and Larrea tridentata. Also, the implanted goats used more (p<0.01) forbs than nonimplanted goats. Results indicated higher proportions of both highly palatable and unpalatable forages in the diet of the TBA-E2 implanted goats compared with control goats which suggests that the administration of these anabolic compounds for an extended period of time modifies food selection of goats in this xeric landscape.
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