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Articles by A. Prakash
Total Records ( 3 ) for A. Prakash
  R. Rathore , A. Rahal , R. Mandil and A. Prakash
  Mimosa pudica is an indigenous antifertility herb. Its use has been advocated against urinary complaints, hypertension, pain relief and menorrhagia but the use has not been scientifically validated till date. Present study was undertaken to delineate the molecular mechanism of tocolytic activity of Hot Methanolic Extract of Mimosa pudica Seeds (HMEMPS) on isolated uterine strips of pregnant buffaloes. Myometrial strips were prepared, mounted in an organ bath containing Ringer Lock’s solution maintained at 37°C and responses recorded using a physiograph in the presence and absence of different antagonists. M. pudica seeds extract produced concentration-dependent inhibitory effect on buffalo myometrium with an EC50 value of 222.4 μg mL-1 perhaps through inhibitory β receptors. Following propranolol (10-6 M) pretreatment, there was an apparent and marked increase in amplitude of spikes of normal spontaneity. An apparent increase in amplitude of spikes upto 1000 μg mL-1 followed by a decrease with further increase in concentration of HMEMPS was also recorded. Verapamil (10-12 M), a Ca+2-channel blocker, apparently could not significantly alter the HMEMPS-induced inhibiton on buffalo myometrium. Calcium channels did not seem to regulate tocolytic effect of Mimosa pudica seeds extract. Further studies are indicated to explore the involvement of Ca2+ and K+ channels, NO and other signaling mechanisms including second messengers.
  Mojjada Ramesh Kumar , C. Yosepu , A. Prakash and D.B.K. Kamesh
  Cloud computing has frequent possible focal points and undertaking applications and information are moving to open or cross breed cloud. Distributed computing guarantees bring down costs, quick scaling, less demanding support and administration accessibility anyplace and whenever. However in regards to some business-basic applications, the associations, particularly vast activities, still wouldn’t move them to cloud. The market estimate the cloud computing offer is still a long way behind the one anticipated. From the buyer’s point of view, cloud computing security concerns, particularly information security and protection assurance issues, remain the essential inhibitor for reception of cloud computing administrations. A late microsoft overview found that “58 % of general society and 86% of business pioneers are amped up for the conceivable outcomes of cloud computing. Be that as it may, more than 90 %of them are stressed over security, accessibility and protection of their information as it rests in the cloud”. A key test is how to guarantee to produce certainty that the cloud can handle client information safely. The purpose of data safety is to ensure secrecy guard, so that, no personal data will be lost or revealed without proper permission.
  Sangeeta Sharma , Shoma Mukherjee , Naveen Kumar , A. Prakash , Fauzia Tabassum , Rachna Agarwal and Kaushal Kumar
  Objective: To study the relationship between Carbamazepine (CBZ) levels and dose in North Indian population. Methods: A retrospective analysis from therapeutic drug monitoring data during 1998-2009 for patient receiving CBZ alone for >4 weeks and sample drawn before the next scheduled dose. Samples drawn for peak levels, suspected non-compliance, overdose and patients with renal/hepatic disorder were excluded. Results: Out of 9310 assays, 2816 fulfilling the criteria were assigned three groups consisting of children 1-18 years (1319), adult 19-60 years (1477) and elderly >60 years (20). Significant differences in mean dose ratio was found in both children and adult, though, was higher in children (0.02±0.01, p<0.01). Significant difference was also found between adult male and females (p<0.01). A negative significant correlation between CBZ daily dose and dose ratio was found in children (r = -0.577, p<0.01) and adults (r = - 0.543, p<0.01). Significant positive linear relation was found between CBZ dose and concentration in children (r = 0.201, p<0.01) and also in adults (r = 0.177, p<0.01) but was not significant in elderly. Conclusion: North Indian children and adult females might attain a higher serum CBZ concentration with the same dose; however larger sample size for elderly should be studied.
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