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Articles by A. Payasi
Total Records ( 2 ) for A. Payasi
  A. Ahmad , M. Chaudhary , A. Soni , A. Payasi and V.K. Dwivedi
  In the present study, the researchers have tried to determine the toxicity of a novel fixed dose combination of ofloxacin plus ornidazole (mebatic) vs. ofloxacin, ornidazole and metronidazole alone drugs in the plasma of Wister rats. Total thirty Wister rats were randomly selected and divided into five groups of six rats each. Group I was control normal saline (0.9% NaCl) treated group where as rest of four groups were treated with respective drugs. The drugs were given to animals intravenously for 24 days and blood samples were collected on 12th and 24th day after treatment for the measurement of biochemical parameters. Present results showed that there was insignificant increase in hemoglobin level on 12th and 24th day in mebatic treated group as compared with other treated groups. The levels of uric acid, alkaline phosphatase, creatinine, bilirubin and hepatic enzymes were found to be lowered but insignificant in mebatic treated group on 12th and 24th day treatment in comparison to ofloxacin, ornidazole as well as metronidazole alone treated groups. These levels were found to be almost near to normal level in mebatic treated group. When ofloxacin, ornidazole as well as metronidazole alone treated groups were compared to control group, these hepatic and renal parameters were significantly increased except in mebatic treated group. The level of free radical mediated damage was also significantly decreased in mebatic treated group in comparison to other treated groups. Therefore, these findings concluded that mebatic drug is less toxic and most effective than ofloxacin, ornidazole and metronidazole alone which improved hepatic and renal enzymes and free radical mediated damage.
  V.K. Dwivedi , A. Soni , A. Payasi , A. Ahmad , Shambhu P. Singh and M. Chaudhary
  The aim of present study was to evaluate the effect of levofloxacin and potentox drugs in osteomyelitis -induced rat model. Staphylococcus aureus 100 μL (1x106 CFU mL-1) was inoculated into the proximal metaphysis of the tibia for induction of osteomyelitis. Body weight and temperature of osteomyelitis-induced rats were monitored every 4th day for three weeks before and after treatment with levofloxacin and potentox. Levofloxacin and potentox were given to animals by intravenously for 21 days. To determine the biochemical parameters (Protein, CRP, Na, Phosphorus, Calcium levels), hepatic enzymes as well as renal function test along with cytokines and malondialdehyde (MDA), myeloperoxidase (MPO) levels in the serum of osteomyelitis-induced untreated and treated groups. Our results showed that the levels of biochemical parameters as well as renal function test along with malondialdehyde, myeloperoxidase levels were significantly altered in the untreated group as compared to levofloxacin and potentox treated groups. When levofloxacin treated group was compared to potentox-treated group, the renal function test and levels of biochemical parameters along with malondialdehyde, myeloperoxidase levels and cytokines were significantly improved in the serum of potentox-treated group. The hepatic enzyme activity was found to be higher in levofloxacin treated group in comparison to potentox-treated group. These study concluded that potentox act as an antioxidant by improving free radical mediated damage and prevents osteomyelitis infection and hepatoxicity in comparison to levofloxacin, caused by Staphylococcus aureus microorganism.
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