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Articles by A. Norhammar
Total Records ( 1 ) for A. Norhammar
  M. Wallander , S. Soderberg and A. Norhammar

Aims High levels of leptin and low adiponectin are associated with Type 2 diabetes mellitus (T2DM) and cardiovascular (CV) disease. We studied the prognostic implications of leptin and adiponectin in patients with acute myocardial infarction (AMI) without previously known Type 2 DM.

Methods One hundred and eighty-one patients were included. Based on an oral glucose tolerance test at hospital discharge (day 4–5), 168 (67% men) had normal or abnormal glucose tolerance (AGT), defined as impaired glucose tolerance or T2DM. Sex- and age-matched healthy persons served as control subjects (n=185). The associations between fasting serum leptin and adiponectin (day 2) and newly discovered AGT and CV events (CV mortality, non-fatal stroke, reinfarction or severe heart failure) during a median follow-up of 34months were investigated.

Results Compared with control subjects, patients of both genders had significantly higher levels of leptin 2days after an AMI. These levels were higher than those obtained at hospital discharge and 3months later. Circulating levels of (ln) leptin 2days after the AMI predicted AGT at discharge (odds ratio2.03, P=0.042). Ln leptin at day 2 was the only biochemical variable that significantly predicted CV events both on univariate [hazard ratio (HR) 1.60, P=0.018] and on multivariate analysis (HR 1.75, P=0.045). Adiponectin levels did not differ between patients and control subjects and did not relate to AGT or CV events.

Conclusions Elevated circulating levels of leptin on the first morning after an AMI are associated with the presence of AGT at discharge and with a poorer long-term prognosis.

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