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Articles by A. Mosaddik
Total Records ( 2 ) for A. Mosaddik
  F. Nikkon , S. Hasan , M.H. Rahman , M.A. Hoque , A. Mosaddik and M.E. Haque
  Two triterpenes, β-Amyrin and 12-Oleanene 3β, 21β-diol, were isolated as a mixture from the chloroform soluble fraction of an ethanolic extract of Duranta repens stem. The structures of these two compounds were confirmed by IR, 1H and 13C-NMR spectral data. In acute toxicity test, the chloroform soluble fraction showed toxic effect on rats but compound 1 (mixture of β-Amyrin and 12-Oleanene 3β, 21β-diol) had no toxic effect on rat at 2 mg/kg/day b.wt. Biochemical and hematological profiles of rat`s blood of chloroform soluble fraction were found statistically significant. In histopathological experiment, some degenerative changes on cellular structure of liver, heart and kidney except lungs were found in chloroform soluble fraction treated rats.
  Sohel Hasan , M.M. Rahman , T. Hossain , A. Mosaddik , S. Khatun and N. Absar
  Among the marine toxins related to human intoxication, tetrodotoxin has been known as one of the most prejudicial. Two tetrodotoxins, namely PFT-1 and PFT-2 were isolated and purified from liver of puffer fish by thin layer chromatography. The structure of both the toxins was elucidated by means of IR, 1H-NMR and 13C-NMR and mass spectroscopy. Sub acute toxicity study showed that both the toxins had pronounced effects on total RBC, WBC, platelet and ESR. Further serum levels of SGPT, SGOT, SALP, bilirubin, creatinine and urea are also affected by the toxins. The histopathological examinations showed that all the tissues such as liver, lung, heart and kidney of rat were severely changed after treatment with the toxins. The toxicity of the purified compounds, PFT-1 and PFT-2 were also performed by brine shrimp lethality bioassay.
 
 
 
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