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Articles by A. Missebukpo
Total Records ( 2 ) for A. Missebukpo
  A. Missebukpo , K. Metowogo , A. Agbonon , K. Eklu-Gadegbeku , K. Aklikokou and M. Gbeassor
  Ixora coccinea L. (Rubiaceae) possess anti-inflammatory and antitussive properties. It is traditionally used for various respiratory ailments including catarrhal bronchitis cough and asthma. In the present study we investigated anti-asthmatic properties of an hydroalcoholic leaf extract of I. coccinea in an ovalbumin (OVA)-induced asthmatic rat model. We also evaluated the anti-allergic property of the extract by Abdominal Wall (AW) method and histamine-induced cutaneous reaction. Rats were sensitized with intraperitoneal (i.p.) ovalbumin and challenged by OVA intranasally to induce chronic airway inflammation. Randomized treatment groups of sensitized rats received I. coccinea extract or distilled water. I. coccinea extract at doses of 1000 and 1500 mg kg-1 suppressed eosinophilia and significantly inhibited AHR in rat with OVA-induced asthma. Based on lung histopathological study using hematoxylin and eosin I. coccinea reduced inflammatory cell infiltration and repaired epithelial cells damaged. In addition the extract at the same doses significantly decreased the diameter of the blue spot (16 and 55%, respectively) compared with the controls and inhibited the skin reactions induced by histamine (23.55 and 53.36%, respectively). In conclusion our results provide evidence that I. coccinea has anti-asthmatic properties and then can support its use in folk medicine to treat asthma.
  K.M. Joppa , K. Métowogo , A. Missebukpo , S. Agbèrè , A. Vovor and K. Aklikokou
  Background and Objective: Chronic anemia is the main cause of death of sickle cell patients. The way to manage their anemia is the stimulating of erythropoiesis by daily folate supplementation with its side effects. This study was aimed to evaluate in vitro antihemolytic and in vivo erythropoietic properties of Morinda lucida leaves hydroalcoholic extract (MLHE). Materials and Methods: The hemolysis was induced by a range of hypotonic solutions of NaCl in the absence and presence of 1.5 and 3 g L1 of MLHE. The toxicity of 28 days was also evaluated for MLHE at the doses of 250, 500 and 1000 mg kg1. Results: MLHE at 1.5 and 3 mg mL1 reduced, respectively 14.7% (p<0.01) and 23.2% (p<0.0001) this hemolysis. On other hand, three days after the anemia induction by phenylhydrazine administration, the reticulocyte rate had increased from 4.6% of red blood cells to 17.6% for the control versus 23.1% (p<0.02) in rats treated with 500 mg kg1 of MLHE. After 28 days of MLHE oral administration (250, 500 and 1000 mg kg1), hematology, nephrology and hepatic parameters showed no significant difference between the control groups and the treated rats. Only the platelets and white blood cells showed significant increasing but this is in the rat standard blood cell counts. Conclusion: The MLHE have anti-anemia properties by increasing the erythropoiesis and osmotic resistance of the red blood cells. Indeed, the results showed that it can admit that MLHE is not toxic.
 
 
 
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