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Articles by A. Mehta
Total Records ( 2 ) for A. Mehta
  S. Hajra , A. Mehta and P. Pandey
  Swietenia mahagoni belongs to Meliaceae family, native to West Indies and commonly known as mahogani. The present study was undertaken to evaluate the antidiarrhoeal activity of the ethanolic, methanolic and aqueous extracts of S. mahagoni seeds at the concentration (50, 100, 200 and 300 mg kg-1 b.wt., p.o) using different experimental model such as castor oil induced diarrhea, enteropooling and gastrointestinal motility were determined by in vivo experimental models. All the extracts showed significant antidiarrhoeal activity in a concentration dependent manner (p<0.05, p<0.01). Among the three solvent extracts; ethanolic extract showed most potent antidiarrhoeal activity as evidenced by the reduction in the rate of defecation and consistency of faeces. Extract produced profound decrease in intestinal transit and significantly inhibited castor oil induced enteropooling comparable to that of intraperitoneal injection of standard drug Diphenoxylate (50 mg kg-1 b.wt.) and atropine sulphate (2.5 mg kg-1 b.wt.). The prolonged onset of diarrhoea, inhibition of castor oil-induced enteropooling and the suppressed propulsive movement observed in this study support the traditional claim of S. mahagoni as an antidiarrhoeal drug in the Indian system of medicine without any side effects. Phytochemical analysis showed the presence of alkaloids, tannins, saponins and carotenoids which may be the active phytoconstituents.
  S. Singh , A. Mehta , S. Baweja , L. Ahirwal and P. Mehta
  Andrographis paniculata and Silybum marianum are well known medicinal plants. However, to prove their efficacy for clinical utilization more scientific data are needed. Therefore, in the present study, an attempt was made to investigate the anticancer potential of hydroalcoholic extracts of A. paniculata and S. marianum and their combination (1:1). The sulphorhodamine B (SRB) assay was used to assess growth inhibition of human tumor. Five human cancer cell lines i.e., human breast adenocarcinoma (MCF-7), human cervix (SiHa), Colon (HT-29), Ovary cancer cell line (ovcar-5) and Liver (HepG2) were used for the above study. The results obtained suggest that S. marianum hydroalcoholic extract showed the best cytotoxic activity against all given cell lines with percentage inhibition of 21.34, 32.30, 46.56, 59.58, 36.20 for MCF 7, SiHa, HT-29, Ovcar-5 and HepG2, respectively. While, A. paniculata hydroalcoholic extract was found most effective against Ovcar-5 with 51.12% inhibition. The combination of both the plants (1:1) showed an intermediate result for all the cell line but, it was found to be most effective against HepG2 with 42.76% inhibition. The results obtained in the study indicate that A. paniculata and S. marianum possess significant anticancer activity and have the therapeutic potential to prevent the cancerous diseases.
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