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Articles by A. Mahesh
Total Records ( 4 ) for A. Mahesh
  R. Jeyachandran , A. Mahesh and L. Cindrella
  Anisomeles malabarica (L.) R. Br. is a traditional medicinal plant of the Labiatae family, distributed throughout India. It has been used in folk medicine for the treatment of cancer and liver disorders. The aim of this work is to study the anticancer effect of crude ethanolic leaf extract of Anisomeles malabarica. Its anticancer activity was evaluated on Diethylnitrosamine (DEN) in mice. The assessment of anticancer activity was evaluated by measuring the activities of total protein, Glutamate Pyruvate Transaminase (GPT), Glutamate Oxaloacetate Transaminase (GOT), Acid Phosphatase (ACP) and Alkaline Phosphatase (ALP). The ethanolic extract at an oral dose of 100 mg kg-1 exhibited a significant (p<0.05) protective effect by reduce liver and serum levels of total protein, GPT, GOT, ACP and ALP as compared to DEN induced mice. These biochemical observations were supplemented by histopathological examination of liver sections. Thus it could be concluded that ethanolic extract of Anisomeles malabarica possesses significant anticancer properties.
  R. Jeyachandran , A. Mahesh , L. Cindrella and X. Baskaran
  It has been well known since ancient times that plants and spices have antimicrobial activity. There has been a considerable interest to use plants and spices for the elimination of microorganisms because of increasing antibiotic resistance of microorganisms. Petroleum ether, chloroform, ethyl acetate, acetone, methanol and aqueous root extracts of Cocculus hirsutus were evaluated for antimicrobial activity against clinically important bacteria viz., Escherichia coli (MTCC 1195), Enterobacter aerogens (MTCC 2823), Klebsiella pneumoniae (MTCC 2405), Salmonella typhi (MTCC 733), Proteus vulgaris (MTCC 1771) and Pseudomonas aeruginosa (MTCC 2642) (gram-negative), Staphylococcus aureus (MTCC 1430) and Bacillus cereus (MTCC 1272) (gram-positive). The in vitro antimicrobial activity was performed by agar disc diffusion method. The results showed the chloroform root extract of Cocculus hirsutus highly affected the activity of Pseudomonas aeruginosa and Bacillus cereus. The inhibition against Staphylococcus aureus and Enterobacter aerogens was moderate and the remaining bacterial strains had no activity. This study suggests that the root of Cocculus hirsutus obtained by infusion can be used in the treatment various bacterial diseases.
  R. Jeyachandran and A. Mahesh
  This study showed the first had information on 57 interesting medicinal herbal plants used by tribal people, Vaidyas, Siddha and Ayurveda for diabetes mellitus. Present enumeration of antidiabetic herbal flora of Tamil Nadu includes information regarding previous findings. This information’s were gathered at the time of field study from various local inhabitants, viz., vaidyas. Medicinal plant seller, healers, priests, hakims and local elderly people. Furthermore, information’s regarding antidiabetic nature of plants were confirmed by previous findings reported in various national and international journals.
  R. Jeyachandran and A. Mahesh
  The evaluation of the activity of the aqueous, methanol and chloroform extracts of the bark of the Kigelia africana (Lam) was tested against E. coli, Enterobacter aerogens, Klebsiella pneumoniae, Salmonella typhi, Proteus vulgaris, Pseudomonas aeruginosa (Gram-negative), Staphylococcus aureus and Bacillus cereus (Gram-positive) by disc diffusion method. The methanol extracts presented a higher activity than the aqueous and chloroform extracts. It exhibits the greatest activity against Salmonella typhi and Proteus vulgaris moderate activity against E. coli, Staphylococcus aureus and Bacillus cereus. The remaining strains viz., Enterobacter aerogens, Klebsiella pneumoniae and Pseudomonas aeruginosa were presented less activity. The inhibition zone was recorded and compared with standard antibiotic drug streptomycin. Results support the traditional use of Kigelia africana (Lam) bark as a good source of antimicrobial agent.
 
 
 
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