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Articles by A. Kimura
Total Records ( 3 ) for A. Kimura
  T Arimura , N Inagaki , T Hayashi , D Shichi , A Sato , K Hinohara , M Vatta , J. A Towbin , T Chikamori , A Yamashina and A. Kimura
  Aims

Z-band alternatively spliced PDZ-motif protein (ZASP)/Cypher is a Z-disc component of which several dilated cardiomyopathy (DCM)-associated mutations have been reported. Most of the mutations were found in exons 4 and 10 of ZASP/Cypher gene LDB3 and both exons were expressed preferentially in the heart. The aim of this study was to investigate the functional alteration of ZASP/Cypher caused by the DCM-associated mutations.

Methods and results

The yeast-two-hybrid method was used to identify the protein bound to a domain encoded by exon 4 of LDB3. Interaction of ZASP/Cypher with the binding protein was investigated in relation to the functional alterations caused by LDB3 mutations. Localization of the ZASP/Cypher-binding protein was examined at the cellular level in rat cardiomyocytes. Phosphoglucomutase 1 (PGM1), a metabolic enzyme involved in glycolysis and gluconeogenesis, was identified as a protein interacting with ZASP/Cypher. PGM1 bound to ZASP/Cypher at the domains encoded by exons 4 and 10. Two LDB3 mutations in exon 4 (Ser189Leu and Thr206Ile) and another mutation in exon 10 (Ile345Met) reduced the binding to PGM1. PGM1 showed diffuse localization in the cytoplasm of rat cardiomyocytes under standard culture conditions, and distribution at the Z-discs was observed under stressed culture conditions. Binding of endogenous PGM1 and ZASP/Cypher was found to be enhanced by stress in rat cardiomyocytes.

Conclusion

ZASP/Cypher anchors PGM1 to Z-disc under conditions of stress. The impaired binding of PGM1 to ZASP/Cypher might be involved in the pathogenesis of DCM.

  M Terauchi , M Koike , K Fukushima and A. Kimura
 

Two types of wavelength-dispersive soft X-ray spectrometers, a high-dispersion type and a conventional one, for transmission electron microscopes were constructed. Those spectrometers were used to study the electronic states of valence electrons (bonding electrons). Both spectrometers extended the acceptable energy regions to higher than 2000 eV. The best energy resolution of 0.08 eV was obtained for an Al L-emission spectrum by using the high-dispersion type spectrometer. By using the spectrometer, C K-emission of carbon allotropes, Cu L-emission of Cu1xZnx alloys and Pt M-emission spectra were presented. The FWHM value of 12 eV was obtained for the Pt M-emission peak. The performance of the conventional one was also presented for ZnS and a section specimen of a multilayer device. W-M and Si-K emissions were clearly resolved. Soft X-ray emission spectroscopy based on transmission electron microscopy (TEM) has an advantage for obtaining spectra from a single crystalline specimen with a defined crystal setting. As an example of anisotropic soft X-ray emission, C K-emission spectra of single crystalline graphite with different crystal settings were presented. From the spectra, density of states of - and -bondings were separately derived. These results demonstrated a method to analyse the electronic states of valence electrons of materials in the nanometre scale based on TEM.

  N. Muthukumar , A. Ilangovan , S. Maruthamuthu , N Palaniswamy and A. Kimura
  Three amide derivatives of 1-aminoanthraquinones (AAQs) synthesized from long chain fatty acids were evaluated for corrosion inhibition efficiency against steel (API 5L-X60) in white petrol–water mixtures at room temperature by weight loss and electrochemical studies. Potentiodynamic polarization studies carried out at room temperature on steel (API 5L-X60) in white petrol with water containing 120 ppm of chloride and 50 ppm of the 1-aminoanthraquinone derivatives showed that all the investigated compounds are of anodic type and good corrosion inhibitors in white petrol–water mixtures. Oleic acid derivative of 1-aminoanthraquinone was found to be the best corrosion inhibitor. It exhibited 86% inhibition efficiency against the corrosion of API 5L-X60 steel. The surface analysis by AFM indicated the adsorption of inhibitors on the metal surface. Besides, all the synthesized 1-aminoanthraquinone derivatives exhibited antimicrobial efficacy against Serratia marcescens ACE2 and Bacillus cereus ACE4.
 
 
 
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