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Articles by A. Jamal Abdul Nasser
Total Records ( 1 ) for A. Jamal Abdul Nasser
  R. Surendra Kumar , Aseer Manilal , A. Jamal Abdul Nasser , Behailu Merdekios , Xiangxiong Chen and A. Idhayadhulla
  Novel diverse 1, 4-dihydropyridine analogues were prepared from cyclization method. Synthesized compounds were characterized from IR, 1H-NMR, 13C-NMR, mass spectral, elemental analysis and mass spectral fragmentation method. The reaction was performed using ordinary condensation type, which enabled to easy work-up and good yield. Synthesized compounds (1-4) were screened for antimicrobial activity. Among these compounds (4) (MIC:8 μg mL-1) has highly antibacterial activity against E. coli compared with standard Ciprofloxacin and compound (4) (MIC: 4 μg mL-1) has highly antifungal active against C. albicans compared with Clotrimazole.The synthesized compounds have been screened for preliminary anti-cancer activity against HepG2 (Liver), Hela (Cervical) and MCF-7 (Breast) cancer cells. The compound (4) is highly active against HepG2, MCF-7 and Hela (Cervical) and these have been selected for advanced preclinical development. Activity has been compared with standard drug. Structure Activity Relationship (SAR) has also been discussed in this study.
 
 
 
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