Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Articles by A. Jamal Abdul Nasser
Total Records ( 1 ) for A. Jamal Abdul Nasser
  R. Surendra Kumar , Aseer Manilal , A. Jamal Abdul Nasser , Behailu Merdekios , Xiangxiong Chen and A. Idhayadhulla
  Novel diverse 1, 4-dihydropyridine analogues were prepared from cyclization method. Synthesized compounds were characterized from IR, 1H-NMR, 13C-NMR, mass spectral, elemental analysis and mass spectral fragmentation method. The reaction was performed using ordinary condensation type, which enabled to easy work-up and good yield. Synthesized compounds (1-4) were screened for antimicrobial activity. Among these compounds (4) (MIC:8 μg mL-1) has highly antibacterial activity against E. coli compared with standard Ciprofloxacin and compound (4) (MIC: 4 μg mL-1) has highly antifungal active against C. albicans compared with Clotrimazole.The synthesized compounds have been screened for preliminary anti-cancer activity against HepG2 (Liver), Hela (Cervical) and MCF-7 (Breast) cancer cells. The compound (4) is highly active against HepG2, MCF-7 and Hela (Cervical) and these have been selected for advanced preclinical development. Activity has been compared with standard drug. Structure Activity Relationship (SAR) has also been discussed in this study.
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility