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Articles by A. Jain
Total Records ( 4 ) for A. Jain
  A. Jain , D. S. Gour , P. S. Bisen , P. P. Dubey , Prashant , D. K. Sharma , A. Bhargava , B. K. Joshi and D. Kumar
  Alpha-lactalbumin (α-LA) (ALA), one of the two major whey proteins, is strongly correlated with the nutritional value and the functional properties of whey and whey products. The genetic variations of ALA gene in Jakhrana Goat breed (Capra hircus) were investigated using an optimized non-radioactive polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis of four amplified fragments covering all four exons of the gene. A total of eight SSCPs patterns were detected in three of these exons in a sample of 50 Jakhrana goats, indicating that this breed has high genetic variability in the ALA gene. This result opens interesting prospects for future breeding programs and conservation strategies. These ALA gene variants can be sequenced and screened in the entire population to develop single nucleotide polymorphisms for association studies with different productive and reproductive performances and marker assisted selection. In addition, our data show that PCR-SSCP is an appropriate tool for evaluating genetic variability.
  K. M. Pantalone , M. W. Kattan , C. Yu , B. J. Wells , S. Arrigain , B. Nutter , A. Jain , A. Atreja and R. S. Zimmerman
  Aims  Sulfonylureas have been shown to increase mortality when used in combination with metformin. This may not be a class effect of sulfonylureas, but rather secondary to differences in properties inherent to the individual sulfonylureas (hypoglycaemic risk, sulfonylurea receptor selectivity and effects on myocardial ischemic preconditioning). The purpose of this study was to assess the risk of overall mortality in patients with Type 2 diabetes treated with different combinations of sulfonylureas and metformin.

Methods  A retrospective cohort study was conducted using an academic health center enterprise-wide electronic health record system to identify 7320 patients with Type 2 diabetes (3768 initiators of glyburide (glibenclamide) and metformin, 2277 initiators of glipizide and metformin and 1275 initiators of glimepiride and metformin), ≥ 18 years of age and not on insulin or a non-insulin injectable at baseline. The patients were followed for mortality by documentation in the electronic health record and Social Security Death Index. Multivariable Cox models with propensity analysis were used to compare cohorts.

Results  No statistically significant difference in overall mortality risk was observed among the different combinations of sulfonylureas and metformin: glimepiride and metformin vs. glipizide and metformin (HR 1.03; 95% CI 0.89-1.20), glimepiride and metformin vs. glyburide (glibenclamide) and metformin (HR 1.08; 95% CI 0.90-1.30), or with glipizide and metformin vs. glyburide (glibenclamide) and metformin (HR 1.05; 95% CI 0.95-1.15).

Conclusions  Our results did not identify an increased mortality risk among the different combinations of sulfonylureas and metformin, suggesting that overall mortality is not substantially influenced by the choice of sulfonylurea.

  A. Amal Raj , K. R. Dutt , H. Kinger , A. Jain , S. Edwin , E. Edwin Jarald and L. Deb
  No Description
  N.S. Gill , S. Dhawan , A. Jain , R. Arora and M. Bali
  These seeds have been traditionally used for various diseases like dysentery, diarrhoea, piles, keeping in mind of their traditional value our present study was to explore wild Punica granatum seeds for its antioxidant and antiulcer potential. The phytochemical screening of the ethanolic seed extract indicates the presence of triterpenoid, sterols, alkaloids, flavonoids, tannins and coumarin glycoside. Antioxidant activity of the wild Punica granatum ethanolic seed extract was measured by 1,1-diphenyl-2-picrylhydrazyl and hydrogen peroxide free radical scavenging method. Further it was evaluated for its anti-ulcer activity by pyloric ligation model in wistar albino rats. Gastric volume, ulcerative index and free and total acidity were measured in this model. The extract showed maximum scavenging activity i.e., 82.80±0.267 and 74.91±0.235 at 100 μg mL-1 by 1,1-diphenyl-2-picrylhydrazyl and hydrogen peroxide method respectively as compared to the standard (ascorbic acid) in case of quantitative analysis and showed yellow coloration with 1,1-diphenyl-2-picrylhydrazyl scavenging radical in case of qualitative analysis. In pyloric ligation method, the extract showed optimum percentage inhibition of 74.51% at 100 μg mL-1 which was comparable to the standard (ranitidine). The present study concludes that wild Punica granatum ethanolic seed extract possesses significant antioxidant and anti-ulcer activities.
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