Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by A. Idhayadhulla
Total Records ( 2 ) for A. Idhayadhulla
  A. Idhayadhulla , R. Surendra Kumar , A. Jamal Abdul Nasser and Aseer Manilal
  New pyrrole derivatives (2,3) were synthesized by condensation method and synthesized compounds were characterized by IR, 1H NMR, 13C NMR, mass and elemental analysis. The novel pyrrole derivatives were screened for anticoagulant activity against Activated Partial Thromboplastin Time (APTT) and Prothrombin Time (PT) coagulation assays and compound (3) is highly response for anticoagulant activity compared with compounds (1) and (2) and standard Heparin at concentration (60 μg mL-1) against APTT assay. The compound 3 showed highly significant anticoagulant effect and could be considered as leads for further investigations.
  R. Surendra Kumar , Aseer Manilal , A. Jamal Abdul Nasser , Behailu Merdekios , Xiangxiong Chen and A. Idhayadhulla
  Novel diverse 1, 4-dihydropyridine analogues were prepared from cyclization method. Synthesized compounds were characterized from IR, 1H-NMR, 13C-NMR, mass spectral, elemental analysis and mass spectral fragmentation method. The reaction was performed using ordinary condensation type, which enabled to easy work-up and good yield. Synthesized compounds (1-4) were screened for antimicrobial activity. Among these compounds (4) (MIC:8 μg mL-1) has highly antibacterial activity against E. coli compared with standard Ciprofloxacin and compound (4) (MIC: 4 μg mL-1) has highly antifungal active against C. albicans compared with Clotrimazole.The synthesized compounds have been screened for preliminary anti-cancer activity against HepG2 (Liver), Hela (Cervical) and MCF-7 (Breast) cancer cells. The compound (4) is highly active against HepG2, MCF-7 and Hela (Cervical) and these have been selected for advanced preclinical development. Activity has been compared with standard drug. Structure Activity Relationship (SAR) has also been discussed in this study.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility