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| Articles
by
A. Hilou |
Total Records (
2 ) for
A. Hilou |
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P.A.E.D. Sombie
,
A. Hilou
,
A.Y. Coulibaly
,
A. Tibiri
,
M. Kiendrebeogo
and
O.G. Nacoulma
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The purpose of the present study was to investigate the protective effects
of the extracts against H2O2-induced hemolysis of erythrocytes
and the neuroprotective potential from galls of Guiera senegalensis. Ethyl
acetate fraction of aqueous decoction extract (EAF/ADE) significantly (p<0.05)
inhibited lipid peroxidation in rat’s brain homogenate in vitro (37.79±0.93%
at 1.25 mg mL-1) when compared to the gallic acid and quercetin used
as positive controls and has the best anti-acetylcholinesterase activity (64.02±4.07%
at 100 μg mL-1). Under the oxidative action of H2O2,
the extracts from galls of G. senegalensis showed significant protection
of the erythrocyte membrane from hemolysis. The Aqueous Decoction Extract (ADE)
contains the highest amount of total tannin (25.3±1.55 mg TAE/100 mg
of extract) content. The erythrocytes hemolysis inhibitory property from galls
of G. senegalensis seems to be related weakly to its total tannin content
(p<0.05). The present study thus suggested that the galls from G. senegalensis
could be used as a new potential source of natural neuro-protective and antioxidant
components. |
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P.A.E.D. Sombie
,
A. Hilou
,
C. Mounier
,
A.Y. Coulibaly
,
M. Kiendrebeogo
,
J.F. Millogo
and
O.G. Nacoulma
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The galls of Guiera senegalensis J.F. Gmel (Combretaceae) are used in Burkina Faso traditional medicine to treat some microbial and metabolic diseases such as malaria, dysentery, diabetes and hypertension. The purpose of the present study was to investigate the phytochemical analysis, the antioxidant and anti-inflammatory inhibitory activities from the galls of Guiera Senegalensis. Phytochemical assay was conducted with following standard protocols. The method of DPPH, FRAP, β-carotene assay, anti-lipid peroxidation (according to the thiobarbituric acid method) studies in vitro were employed to assess the antioxidant efficacy. The xanthine oxidase and lipoxygenase inhibition properties of extracts and fractions were also evaluated to assess the anti-inflammatory activity from galls of Guiera senegalensis. Galls extracts of G senegalensis are rich in totals polyphenol and in totals flavonoid content. The hydroacetonic extract showed the most potent antioxidant activity in FRAP method (10.88±0.86 mmol AEAC g-1) and anti-lipid peroxidation activity (75.06±2.42%) at a concentration of 1.25 mg mL-1. The water fraction of hydroacetonic extract showed the most potent antioxidant activity (6.012±0.13 mmol AEAC g-1 ) in the DPPH radical scavenging method and butanol fraction of hydroacetonic extract in the β-carotene bleaching method (59.00±3.27%) at a concentration of 100 μg mL-1. The highest antioxidant activity can be positively correlated with the highest total phenolics content and also with the highest anti-inflammatory activity of the tested extract/fraction. The present study thus provides a scientific rationale for the traditional use of this plant product to the treatment of metabolic diseases. |
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