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Articles by A. Hamid
Total Records ( 3 ) for A. Hamid
  N. Awang , N.F. Kamaludin , A. Hamid , N.W.N. Mokhtar and N.F. Rajab
  Studies on the discovery of new cancer treatment by using metal-based compounds such as tin (Sn) has now greatly being synthesized and evaluated to identify their effectiveness and suitability to be developed as a new anticancer drug. Approach: This study was carried out to evaluate the cytotoxicity of triphenyltin(IV) methylisopropyldithiocarbamate (compound 1) and triphenyltin(IV) ethylisopropyldithiocarbamate (compound (2) on chronic myelogenus leukemia cells. The determination of their cytotoxicity (IC50) at different time of exposure and concentration was carried out through the employment of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay. Results: The IC50 values obtained for compound 1 and 2 following treatment at 24, 48 and 72 h were 0.660, 0.223, 0.370 μM and 0.677, 0.306, 0.360 μM, respectively. Cell morphological changes such as apoptotic and necrotic features were also been observed. Conclusion: The compounds tested were found to give cytotoxic effect against chronic myelogenus leukemia (K-562) cell at a micromolar dose. Thus, further study on their specific mechanism of actions in the human cells should be carried out to elucidate their potential as an anticancer agent.
  D.K. Biswas , M.M. Haque , A. Hamid and J.U. Ahmed
  Pot experiment was conducted to asses the temporal effects on gas exchange characteristics of blackgram at different growth stages. Two blackgram varieties namely BARImash 3 and BINAmash 1 were sown at 10 days interval on August 26, September 6, September 16 and September 26 of 1999. At each sowing time, photosynthetic gas exchange characteristics were measured at vegetative, flowering, pod filling, early maturity, mid maturity and late maturity stages of blackgram. Varietal difference was minimal but sowing time had profound effects on gas exchange characteristics of blackgram. Photosynthetic rate was higher in blackgram leaf sown on August 26 with its higher stomatal conductance, lower intercellular CO2 concentration and higher mesophyll conductance. The highest respiration rate was recorded at pod filling stage and fluctuated widely over the sowing times. Photosynthetic rate of blackgram decreased with delay in sowing times and the lowest rate was observed on September 26 sowing. Gas exchange characteristics were the highest at flowering stage of blackgram and declined gradually with the advent of plant age.
  N.Z.M. Saat , B. Mohandas , A.R. Ghazali , I. Ishak , S.H. Lubis , N. Mohamed , A. Hamid , Z.A. Hamid and H. Othman
  Heavy metals such as Arsenic (As), Cadmium (Cd) and Plumbum (Pb) in fertilizers and pesticides could cause health problems to human. The sources of exposure to these heavy metals can be ingestion, food and the use of pesticides and fertilizers in agricultural. A study was conducted in Kelantan among farmers. The purpose of this study was to determine levels of heavy metals according to gender, age group, blood pressure, smoking habits and period of time exposure to pesticide (years). There were 113 farmers participated in this study. The samples of hair and nails were collected from farmers. The levels of heavy metals such as As, Cd and Pb were determined using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). The results, showed that there was mean differences of Pb levels between age groups in hair samples (p<0.05). Furthermore, using the pearson correlation, the results indicated that there was significant relationship between working experience and the level of Pb (r = -0.020, p<0.05). However, there was no significant difference of Cd, Pb, As between gender, level of blood pressure (high, normal and low), smoking habit and residences in nails and hair sample. In conclusion, the levels of heavy metals was higher in nails compare to hair samples. The heavy metals was higher among male, older age group, hypertension and non-smoker.
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