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Articles by A. Dehghan
Total Records ( 5 ) for A. Dehghan
  A. Dehghan , A.A. Mahjoor , H. Bazyar and K. Zangili
  Silymarin, a natural hepatoprotector, extracts from Silybum marianum. It seems that silymarin can modulate metabolic changes in the liver and pancreas, also Food Restriction (FR) affects their metabolism. The aim of the study was the evaluation of concurrent effects of silymarin and food restriction on metabolic functions of liver and pancreas to improve their treatment response. Sixty female Wistar rats were divided into six equal groups. Control group were fed ad libitum (Non-FR). Rats in other groups received 50% of the food intake of Non-FR group and served as FR groups. Three of five FR groups received 100, 200 and 400 mg kg-1 silymarin, respectively. The fourth FR group received placebo. The last FR group and the Non-FR group did not receive any silymarin. Food restriction decreased serum triglycerides in all FR groups (p<0.01). Administration of 100 mg kg-1 of silymarin to FR rats increased serum triglycerides levels (p = 0.02). Food restriction significantly decreased ALT and ALP which may relate to decrease in liver functional mass. The compare of serum amylase levels in FR and Non-FR groups showed that food restriction, except in FR-100 group, decreased these levels (p<0.05). Present results showed no constant change on glucose and triglyceride levels by silymarin. It seems that silymarin is a modulator of metabolic factors, such as glucose and triglyceride, which needs further researches. Also, concurrent use of food restriction and silymarin doesn’t have any adverse effect on pancreas and hepatobiliary system and can be used simultaneously to increase their benefits.
  A. Dehghan , M. Arabi , S. Nahid and M. Aminlari
  Oxidative stress commonly occurs following heat stress in tropical regions and affects dairy animals. Glutathione protects cells from oxidative damages. This study was carried out to investigate the serum glutathione level in the ram with a fluorometric method and to determine its changes during heat stress condition. Eight mature rams were selected and kept in the same conditions. The rams were maintained during temperate and warm seasons to compare serum glutathione levels during normal and heat stress conditions, respectively. Heat stress was considered when temperature-humidity index was above 84. Serum samples were obtained at 0, 14 and 28 days after beginning of the study during the seasons. Reduced and oxidized glutathione concentrations were determined using a fluorometric assay. The serum concentrations of reduced glutathione in the normal and heat stress conditions were lower than oxidized glutathione. The reduced and oxidized glutathione levels and their ratios were not different between seasons and at different sampling times, although they were significantly changed during sampling times in the normal and heat stress conditions. Present results represent that glutathione levels change during different environmental conditions. It seems that antioxidant defense system was changed to adapt and prevent oxidative stress effects, although needs further researches.
  B. Guigas , J. E. de Leeuw van Weenen , N. van Leeuwen , A. M. Simonis-Bik , T. W. van Haeften , G. Nijpels , J. J. Houwing-Duistermaat , M. Beekman , J. Deelen , L. M. Havekes , B. W. J. H. Penninx , N. Vogelzangs , E. van t Riet , A. Dehghan , A. Hofman , J. C. Witteman , A. G. Uitterlinden , N. Grarup , T. Jorgensen , D. R. Witte , T. Lauritzen , T. Hansen , O. Pedersen , J. Hottenga , J. A. Romijn , M. Diamant , M. H. H. Kramer , R. J. Heine , G. Willemsen , J. M. Dekker , E. M. Eekhoff , H. Pijl , E. J. de Geus , P. E. Slagboom and L. M. t Hart
 

Aims

Modulation of dopamine receptor D2 (DRD2) activity affects insulin secretion in both rodents and isolated pancreatic β-cells. We hypothesized that single nucleotide polymorphisms in the DRD2/ANKK1 locus may affect susceptibility to Type 2 diabetes in humans.

Methods

Four potentially functional variants in the coding region of the DRD2/ANKK1 locus (rs1079597, rs6275, rs6277, rs1800497) were genotyped and analysed for Type 2 diabetes susceptibility in up to 25 000 people (8148 with Type 2 diabetes and 17687 control subjects) from two large independent Dutch cohorts and one Danish cohort. In addition, 340 Dutch subjects underwent a 2-h hyperglycaemic clamp to investigate insulin secretion. Since sexual dimorphic associations related to DRD2 polymorphisms have been previously reported, we also performed a gender-stratified analysis.

Results

rs1800497 at the DRD2/ANKK1 locus was associated with a significantly increased risk for Type 2 diabetes in women (odds ratio 1.14 (1.06-1.23); = 4.1*10−4) but not in men (odds ratio 1.00 (95% CI 0.93-1.07); = 0.92) or the combined group. Although rs1800497 was not associated with insulin secretion, we did find another single nucleotide polymorphism in this locus, rs6275, to be associated with increased first-phase glucose-stimulated insulin secretion in women (= 5.5*10−4) but again not in men (= 0.34).

Conclusion

The present data identify DRD2/ANKK1 as a potential sex-specific Type 2 diabetes susceptibility gene.

  M.M. Hadipour , S.H. Farjadian , F. Azad , M. Kamravan and A. Dehghan
  H9N2 avian influenza virus is responsible for the majority of death in Iranian poultry farms due to renal damage. For understanding the nephropathogenicity of H9N2 avian influenza virus in commercial broiler chickens, thirty 20 days old chickens were intratracheally inoculated with 106 EID50 per bird with A/Chicken/Iran/SH-110/99 (H9N2) avian influenza virus. Then on days 1, 2, 4, 6, 8 and 10 Post-Inoculation (PI) samples of the kidney were collected for histopathologic studies. In inoculated chickens tubulointerstitial nephritis in the kidney were observed on days 6, 8 and 10 PI. The results indicated that the A/Chicken/Iran/SH-110/99 (H9N2) avian influenza virus after IT inoculation has pathogenicity for kidney (nephrotropic).
  A.A. Mahjoor and A. Dehghan
  This study was conducted to evaluate the changes in serum metabolic factors of over conditioned pregnant rats treated with silymarin in food restriction condition. Sixty pregnant Wistar rats were divided into five equal groups. All rats received high energy diet before treatments. Control group were fed ad libitum (Non-FR). Rats in other groups received 50% of the food intake of Non-FR group and served as food-restricted (FR) groups. Three of five FR groups received 150, 200 and 400 mg kg-1 silymarin, respectively (FR-150, 200, 400). Another FR group (FR-Con) and the Non-FR group did not receive any silymarin. Glucose, triglyceride, LDL and HDL cholesterol, total cholesterol, thyroid hormones and cortisol were measured in serum. All factors were significantly different between groups except free-T4 and T4. Serum glucose concentrations in FR-150 and 200 and Non-FR groups were lower than FR-Con and FR-400. Silymarin significantly increased serum triglycerides, LDL cholesterol and cholesterol contents in FR groups. The highest levels of these factors were noted in 200 mg silymarin-treated group. HDL cholesterol was highest in FR-Con; meanwhile FR-200 group had the lowest HDL cholesterol. Serum cortisol decreased in treated and untreated FR groups except FR-150 group. Free-T3 and T3 concentrations in FR-400 and FR-Con groups were higher than the other silymarin treated groups. In conclusion our results indicate that 200 mg kg-1 of silymarin in Wistar rats is the best dosage to achieve metabolic benefits. Silymarin has positive effects on lipid metabolism and can modulate serum triglyceride and cholesterol concentrations in food restriction condition. Also, the present findings suggest that silymarin under food restriction situation exerts a decreasing effect upon peripheral conversion of T4 to T3.
 
 
 
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