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Articles by A. Amit
Total Records ( 4 ) for A. Amit
  A. J. Joshua , K. S. Goudar , N. Sameera , G. Pavan Kumar , B. Murali , N. Dinakar and A. Amit
  Problem statement: Herbal remedies form one of the effective strategies for management of livestock healthcare. Despite the availability of extensive pharmacological information, the toxicological data on herbs and herbal preparations seem to be scanty. The objective of the present investigation was to evaluate the acute oral toxicity of some herbal veterinary preparations in albino Wistar rats. Approach: In the sighting study, the investigational substances (Rumbion™ and Tyrel™) were orally administered in sequential manner to one animal each at 2000 and 5000 mg kg-1 body weight followed by four animals at 5000 mg kg-1 body weight in the main study. The treated animals were observed for mortality, adverse clinical signs, changes in body weight gain and necropsy findings during the study. Results: The results of the present study revealed that the treated rats survived throughout the study period and did not exhibit any treatment related abnormal clinical signs at the tested dose levels. Overall, the percent body weight gain in rats treated with the herbal preparations was found to be normal during the 14 day observation period. Postmortem examination of rats did not reveal any major abnormalities. Conclusion: In summary, acute oral toxicity testing of herbal veterinary formulations did not cause any treatment-related adverse effects up to the dose level of 5000 mg kg-1 body weight and hence the tested products were labeled unclassified in the hazard category according to Globally Harmonised System.
  A.J. Joshua , K.S. Goudar , A. Damodaran , N. Sameera and A. Amit
  The present study was conducted to evaluate the acute oral toxicity potentials of certain herbal veterinary preparations in albino Wistar rats. In the sighting study, the test substances were administered in sequential manner to one animal each at 2000 and 5000 mg kg-1 body weight followed by four animals at 5000 mg kg-1 body weight in the main study; whereas the test materials with well documented traditional use were evaluated at 5000 mg kg-1 body weight. The treated animals were observed for mortality, untoward clinical/toxic signs, alterations in body weight gain and necropsy findings during the study. The treated animals survived throughout the study period and did not reveal any treatment related major abnormal clinical signs at the tested dose levels for all the products. The overall percent body weight gain in rats treated with the herbal products was found to be normal during the 14 day observation period. On necropsy, no abnormalities were observed. In conclusion, acute oral toxicity testing of screened herbal veterinary products did not produce any treatment-related adverse effects upto the dose level of 5000 mg kg-1 body weight.
  Harshad C. Barbhaiya , Rajeshwari P. Desai , Vinod S. Saxena , K. Pravina , P. Wasim , P. Geetharani , J. Joshua Allan , K. Venkateshwarlu and A. Amit
  A randomized double blind placebo controlled study was designed to evaluate the efficacy and tolerability of BacoMind®, an enriched phytochemical composition from Bacopa monnieri on memory improvement upon chronic administration in elderly subjects as memory loss in elderly people is one of the leading health problems worldwide and its uncertain recovery with conventional therapies has paved way to elucidate the use of complementary and alternative system of medicine. Elderly individuals with mini mental state examination score of twenty four and above were enrolled. BacoMind® or placebo was given as a single oral dose of 450 mg daily for the duration of 12 weeks. The combination of well established battery of neuropsychological tests revealed that BacoMind® improved performance in tests associated with attention and verbal memory in elderly participants. Significant interaction effects between group and time were observed in digit span backward test (p = 0.008), list learning delayed recall test (p = 0.014), paired associates dissimilar delayed recall test (p = 0.047) and in visual retention-I test (p = 0.035). In conclusion, the study findings suggested that BacoMind® improved the cognitive functions such as attention and verbal memory in elderly individuals and was also found to be well tolerated.
  V. Vijayabalaji , J. Joshua Allan , G. Pavan Kumar , B. Murali , M.L. Suryanarayana and A. Amit
  The objective of the current study was to assess the acute oral toxicity of some herbal veterinary preparations in female albino Wistar rats as per the OECD guidelines for testing of chemicals, Acute oral toxicity-Fixed dose procedure (Test guideline 420). The investigational substances, NaturalivTM liquid and Zist® liquid are used in poultry for hepatoprotective and antioxidant properties, respectively. NaturalivTM liquid was tested at 5000 mg kg-1 b.wt., whereas Zist® liquid was evaluated in sequential manner to one animal each at 2000 and 5000 mg kg-1 b.wt. in the sighting study, followed by four animals at 5000 mg kg-1 b.wt. in the main study. The treated animals were observed for mortality (twice daily), adverse clinical signs (once daily), changes in weekly body weight gain and gross necropsy findings. All the treated animals survived throughout the study period. Treatment with NaturalivTM liquid did not reveal any abnormal clinical signs at the tested dose level while Zist® liquid treated rats exhibited few clinical signs for a transient period on the day of dosing. The overall percent body weight gain in rats was found to be normal during the 14 day observation period. The terminal sacrifice revealed no gross pathological lesions that can be attributable to treatment. Based on this, it can be stated that NaturalivTM liquid and Zist® liquid, on single oral administration to female Wistar rats, were found to be safe up to 5000 mg kg-1 b.wt.
 
 
 
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