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Articles by A. Aigbiremolen
Total Records ( 2 ) for A. Aigbiremolen
  O.I. Iribhogbe , U. Akpamu , J.E. Emordi , A. Aigbiremolen , E.O. Nwoke and B. Idinoje
  The effect on electrolyte profile following oral administration of antioxidants (vitamin A, C and E supplements in early pregnancy was investigated using albino rats of the Wistar strain. Eighty-five female rats weighing between 255-300 g were used for the study. They were randomly assigned to three study groups having 5 sub groups with five animals each, a control and vehicle group with five animals each. After pregnancy has been confirmed, the control group was administered 1 mL of distilled water, vehicle group 1 mL of tween 80, while test groups 1, II and III received different doses of vitamin A, C and E, respectively via the intragastric route for 11 days. The administration of vitamin A, C and E in early pregnancy for 11 days produced insignificant changes in serum Na+ levels (p>0.05) and a significant increase in serum Ca2+ level. With the exception of vitamin C, vitamin A and E produce a significant increase in serum K+ and Cl¯ levels. Conclusively administration of vitamin A, C and E in early pregnancy cause no significant alteration in serum Na+ levels. However, care must be taken when vitamin A and E are administered with agents that elevate serum Ca2+ and K+ levels as this may pontentiate hypercalcemia and hyperkalemia, respectively in early pregnancy.
  O.I. Iribhogbe , A. Aigbiremolen , U. Akpamu , J.E. Emordi and E.O. Nwoke
  The purpose of this study is to evaluate the effects of vitamin A, C and E supplementation on lipid profile in early pregnancy. A total of 85 adult female wistar albino rats weighting 225-300 g were used and randomly grouped into 5 groups (2 control groups of five rats each, 3 test groups with 5 sub- groups of 5 rats each). After, pregnancy was confirmed, the control groups were administered distilled water and tween 80 respectively, while test groups A, C and E received vitamin A, C and E supplements, respectively. At the end of the 11th day of the experiment, blood samples were collected and TC (total cholesterol), TG (Triglyceride), LDL-C (low density lipoprotein cholesterol and HDL-C (high density lipoprotein cholesterol) were assayed using standard procedure. The test group had significantly increased TC, LDL- C and HDL- C but decreased TG levels following vitamin A administration when compared with control (p<0.05). The group supplemented with vitamin C also had significantly higher TC, TG and LDL- C and unchanged HDL-C compared with control (p<0.05). The group supplemented with vitamin E had a non significant TC levels, a significantly increased TG and HDL- C and a significantly reduced LDL- C levels (p<0.05). Based on results observed, we suggest that, in pregnancy, dietary supplementation with Vitamin A and E may be cardioprotective. This is because vitamin A and E significantly increase HDL- C, although this is accompanied by increase of other serum lipid component. Vitamin C, however was not beneficial.
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