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Articles by A. Zuraini
Total Records ( 4 ) for A. Zuraini
  M.N. Somchit , A. Zuraini , A. Ahmad Bustamam , N. Somchit , M.R. Sulaiman and R. Noratunlina
  The hepatoprotective activity of the ethanol extract of Curcuma longa was investigated against paracetamol (acetaminophen, 4-hydroxy acetanilide)-induced liver damage in rats. Paracetamol at 600 mg kg-1, induced liver damage in rats manifested by statistically increased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). Histologically, livers from these rats revealed parenchymal necrosis and massive inflammation. Pretreatment of rats with the ethanolic extract of Curcuma longa (100 mg kg-1) prior to paracetamol dosing lowered serum liver enzyme activities. Livers of these rats showed normal histology. These results suggested that ethanolic extract of Curcuma longa has potent hepatoprotective effect against paracetamol-induced liver damages in rats.
  M.N. Somchit , M.H.N. Shukriyah , A.A. Bustamam and A. Zuraini
  The objective of the present study was to evaluate the anti-pyretic and analgesic activities of aqueous and ethanol extracts of Zingiber zerumbet rhizomes. The anti-pyretic activity of Zingiber zerumbet (25, 50 and 100 mg kg-1) was studied in Brewer`s yeast-induced pyrexia in rats. The analgesic activity of Zingiber zerumbet (10, 25, 50 and 100 mg kg-1) was studied using acetic acid-induced writhing in mice. Both aqueous and ethanol extracts of Zingiber zerumbet showed significant anti-pyretic activities in Brewer`s yeast-induced pyrexia in rats throughout the observation period of 8 h. The ethanol extract of the rhizomes of Zingiber zerumbet however significantly decreased the writhing movements in mice in acetic acid-induced writhing test. In conclusion, rhizomes Zingiber zerumbet have both analgesic and anti-pyretic activities.
  A. Zuraini , M.R. Ros Aziah , A.K. Arifah , M.R. Sulaiman and M.N. Somchit
  The aim of present study was to investigate the potential roles of aqueous extracts of A. paniculate in lowering the plasama lipid parameter which is responsible for hyperlipidemia and its damaging consequences and also to determine the kidney and liver functions of rats. Plasma Total Cholesterol (TC), Low Density Lipoproteins (LDL) cholesterol and Triglycerides (TG) had progressively increased in cholesterol-fed rats up to 4 weeks of cholesterol-feeding. Both 100 and 200 mg kg 1 concentrations of A. paniculata extracts had kept TC, LDL and TG values within the normal range even after 4 weeks of feeding. No significant enhancement was found in the amount of High Density Lipoproteins (HDL) cholesterol and the kidney and liver enzymes of the rats, i.e. Blood Urea Nitrogen (BUN), total creatinine and Lactate Dehydrogenase (LDH) and Aspartate Amino Transferase (AST) and Alanine Aminotransferase (ALT), respectively indicating normal kidney and liver functions. From the current study, it can be concluded that 100 and 200  mg kg 1 aqueous extract of A. paniculata appeared to possess great potentials as anti-hyperlipidemic agent in rats.
  M.N. Somchit , S. Faizah , A. Zuraini , H.M. Khairi , A.H. Hasiah and Z.A. Zakaria
  Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are heterogenous group of compounds used to cure and prevent inflammation. It was demonstrated that NSAIDs has the ability to inhibit the viability of colon cancer cells in vitro. We investigated the effects of Piroxicam and mefenamic acid on the viability of 4 cancer cell lines in which 2 of them are colon cancer cell lines (HCT 116 and CaCo-2). Cell viability was determined using MTT assay. Both NSAIDs was observed to markedly decrease the cell viability of both cell lines (HCT 116 and CaCo-2). Piroxicam was statistically more cytotoxic towards the cancer cell lines when compared to mefenamic acid. However, the cytotoxic effect of NSAIDs was less potent on breast cancer cells (MCF-7) and liver cancer cells (Hep G2). In conclusion, piroxicam and mefenamic acid showed selective cytotoxic effects against colon cancer cells but not against liver or breast cancer cells.
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