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Articles by A. Y. K. M. Masud Rana
Total Records ( 3 ) for A. Y. K. M. Masud Rana
  J. A. Khanam and A. Y. K. M. Masud Rana
  The research work has been undertaken in order to investigate the antineoplastic activity of chloroacetohydroxamic acid (CHA) in combination with bleomycin against Ehrlich ascites carcinoma (EAC) in Swiss Albino mice. Results showed that combination of treatment inhibits the tumor growth to more than 90% as against 56 and 65% for CHA and bleomycin, respectively. The combination treatment increases the life span of EAC bearing mice to 70% as against 30 and 50% for CHA and bleomycin, respectively. The combination treatment also recovers the hematological parameters and alkaline phosphatase (ALP) activity of tumor bearing mice more precisely than do CHA and bleomycin, individually.
  J. A. Khanam , M. Akhtaruzzaman , A. Y. K. M. Masud Rana and M. Shajahan
  A new compound 2,2-diamino-1-azavinyl aminoamide was synthesized by the reaction of hydrazine hydrate and urea. It was screened against eleven bacteria for its antibacterial activity. At dose 30 μg disc-1 tested compound shows diameter of zone of inhibition within the range 12-24 mm against all of the tested bacteria which was found to be larger range as compared to kanamycin (27-36 mm) at the same dose. Minimum inhibitory concentration was obtained against Shigella dysenteriae, Salmonella typhi and Sarcina lutea with in the range of 8-16 μg ml-1. The brine shrimp lethality of the compound was found to be 8.12 μg ml-1. The tested compound possesses a pronounced cytotoxic effect as observed from mortality rate of brine shrimp nouplii but the compound (10 mg kg-1) had no major toxic effect on hematological parameters in mice. In conclusion, the tested compound, 2,2-diamino-1-azavinyl aminoamide may be considered as a new one having potential antibacterial activity with less toxic effect on hematological parameters.
  J. A. Khanam , S. Roy and A. Y. K. M. Masud Rana
  Antitumor activity of sodium salt of cyanohydroxamic acid (CNHA) has been evaluated against Ehrlich ascites carcinoma (EAC) in mice. CNHA inhibited the growth of EAC cells and enhance the longitivity of tumor bearing mice significantly. Hematological parameters and alkaline phosphatase (ALP) activity in tumor bearing mice are found to be significantly altered but CNHA treatment recovered those parameters towards normal values. High mortality rate of brine shrimp nouplii was obtained with CNHA exhibiting pronounced cytotoxic effect.
 
 
 
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