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Articles by A. H. Young
Total Records ( 2 ) for A. H. Young
  S. A McIsaac , A Westrin and A. H. Young
 

Significant evidence has accrued suggesting that the hypothalamic–pituitary–adrenal (HPA) axis plays a role in some psychiatric disorders. This article reviews the physiology of the HPA axis, evidence of dysfunction in this axis in psychiatric illnesses and the role that this dysfunction might play in pharmacological treatment resistance. Future therapeutic strategies that may potentially arise from these researches are briefly outlined.

  K. A. N Macritchie , A. J Lloyd , M. E Bastin , K Vasudev , P Gallagher , R Eyre , I Marshall , J. M Wardlaw , I. N Ferrier , P. B Moore and A. H. Young
 

Background

Abnormal diffusion parameters are reported in specific brain regions and white matter tracts in bipolar disorder.

Aims

To investigate whether these abnormalities are generalised, and thus evident in large regions of white matter.

Method

Diffusion parameters were measured at several regions in the corpus callosum and in deep/periventricular white matter in 28 currently euthymic patients with bipolar disorder and controls. White matter hyperintensity loads were assessed.

Results

Comparing the whole data-sets using the sign test, in the group with bipolar disorder, mean diffusivity was greater at all 15 sites (P<0.001) and fractional anisotropy was reduced at 13 (P<0.01). The effect of diagnosis was significant for callosal mean diffusivity and fractional anisotropy and for deep/periventricular mean diffusivity (MANCOVA). Comparing individual regions (Mann–Whitney U-test), prefrontal and periventricular mean diffusivity were significantly increased; callosal and occipital fractional anisotropy were significantly reduced. Former substance use and lithium were possible confounding factors. Periventricular white matter hyperintensities were associated with significantly increased periventricular mean diffusivity in individuals with bipolar disorder.

Conclusions

Generalised white matter microstructural abnormalities may exist in bipolar disorder, possibly exacerbated by past substance use and ameliorated by lithium.

 
 
 
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