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Articles by A. Ghavamzadeh
Total Records ( 2 ) for A. Ghavamzadeh
  A.R. Ardjmand , K. Alimoghadam , S. Kaviani , A. Ghavamzadeh , M. Djahani and L. Moezzi
  Arsenic trioxide (ATO) has been reported to induce apoptosis in Leukemic cells of Acute Promyelocytic Leukemia (APL) patients through different pathways. However, the exact mechanism of ATO-induced apoptosis is not yet clear. Co stimulation of death receptors CD30 and tumor necrosis factor receptor type one (TNFR-I) is one of the postulate mechanisms which in the present study we aimed to evaluate their involvement in fresh Promyelocytic cells separated from bone marrow of APL patients. Immunomagnetic separated cells were treated up to 48 h at clinically tolerable concentration of ATO (0.5-2.0 μmol L-1) and expression of TNFR-I and CD30 were evaluated within the apoptotic and live populations using a sensitive triple color flow cytometric method for measuring apoptosis in combination with dual color immunofluorescence. Present results suggest that the expression of TNFR-I and CD30 might not be related to ATO-induced apoptotic cell death.
  M. Parsa , S.N. Najafi , N. Jonaidi Jafari , M. Mohraz , A. Ghavamzadeh , B. Bahar , M. Izadi , M.H. Radfar and H. Ghofrani
  The present study was designed to determine diagnostic value of IL-6 and TNF-α in patients with fever and neutropenia. This is a prospective study of 133 patients admitted to two university hospital in Tehran, Iran with fever and neutropenia. Patients were divided two groups as low risk and high-risk groups. Cytokines level compared with Mann-Whitney test in study groups of patients and ROC curves used to determine best cut-off points level for cytokines discriminating risk groups. Mean age of patients was 26.8±2.5 years and 7.5% of patients allocated in low risk group. The mean IL-6 and TNF-α serum level below 17 pg mL-1 was defined as best cut-off point determining low risk group patients with sensitivity and specificity of 70 and 67.5% respectively. However, we cannot define a statistically significant cut-off point for TNF-α to use as a diagnostic test. 13.5% of patients of our study have positive blood cultures (6% gram-negative, 6% gram- positive, 1.5% fungi), but no statistical difference had found in serum IL-6 and TNF-α levels in blood culture groups. Despite our findings about IL-6 diagnostic value in neutropenic patients with fever and its advantages in discriminating risk groups of patients it seem necessary to design a randomized controlled trial before use of this marker.
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