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Articles by A. Arun Prince Milton
Total Records ( 2 ) for A. Arun Prince Milton
  M.A. Ravichandran , M. Saminathan , A. Arun Prince Milton , K. Dhama , C. Suresh , K. Jeeva and S.K. Misra
  Cytogenetic studies in domestic animals are gaining more importance because of their genetic implications to breeding programmes. The present study describes the chromosome profile and morphometric characteristics of Garole and Bonpala sheep and comparison of chromosomes between males, females and between breeds. The Karyotype revealed diploid chromosome number of 54 (2n) in both breeds and sexes. The first three pairs of autosomes were bi-armed, submetacentric and remaining 23 pairs were acrocentric. The X-chromosome was acrocentric and largest and Y-chromosome was the smallest, biarmed and metacentric. The morphometric analysis showed significant variation in mean relative length of 13th chromosome pair of Garole and Bonpala males and significant variation in the arm ratio of 2nd chromosome pair of females and variation also noticed in almost all the pairs of chromosomes but not up to the level of significance. The mean relative length of autosomes of Garole and Bonpala male ranged from 1.39±0.05 to 11.45±0.15 and 1.48±0.06 to 11.69±0.25 percentage, respectively. The mean relative length of X-chromosome of the males was 5.66±0.15 and 5.83±0.17, respectively while the Y-chromosome length was 1.20±0.02 and 1.27±0.06, respectively. The mean relative length of autosomes of the females ranged from 1.43±0.06 to 10.80±0.20 and 1.42±0.04 to 11.42±0.36, respectively. The mean relative length of X-chromosome of Garole and Bonpala female was 5.51±0.13 and 5.61±0.15, respectively. The mean arm ratio of first 2 pairs of autosomes of Garole male was higher than Bonpala male while the 3rd pair was higher in Bonpala males. The mean arm ratio of first 3 pairs of autosomes of Garole female was higher than Bonpala female. The present study for the first time compares the cytogenetic profile between Garole and Bonpala sheep breeds.
  I. Mohanty , K. Arunvikram , D. Behera , A. Arun Prince Milton , G. Elaiyaraja , G. Rajesh and K. Dhama
  The evolution of poison and venom had made the animal body system to deal effectively with defense mechanism primarily by molecular means. These chemical defences target the cell membrane receptors, block the physiological systems in body and cause paralysis. Evolution around years, led to the development of these peptides with effective functional properties that made them more selective and potent, but immunogenically poor, provide prolonged action and potent effect on preys. When a venom or toxin is enriched with these functionally effective peptides form 3D structure that are linked by disulphide brides. This structure is highly stable and they specifically target GPCRs, ion channels and other membrane receptors and it was proved to have indispensable pharmacological properties. The first drug Captopril discovered against hypertension was isolated from Brazilian viper, Bothrops juraraca. It is one of the most popular and accepted antihypertensive drug used world wide now-a-days. Since then peptides isolated from snake, scorpion, spider, bee and sea anemone toxin have proved to display potential immunomodulatory effects and were useful in treating rheumatoid arthritis, multiple sclerosis, lupus and psoriasis including autoimmune diseases in human. The present article in not intended to be a definitive review of entire field of zootoxins, but rather an overview, which emphasize on recent developments made in the field of zootoxins (venoms and toxins), their role in the treatment of diseases with a special focus towards exploring their potent immunodulatory and therapeutic potential in the field of drug development. Advances in the fields of analytic chemistry, molecular biotechnology and biochemistry are now making it possible to isolate and purify individual components, using a minute amount of a toxin.
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