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Articles by A Wu
Total Records ( 2 ) for A Wu
  J. Y Tang , A Wu , E Linos , N Parimi , W Lee , M Aszterbaum , M. M Asgari , D. R Bickers and E. H. Epstein
 

Objectives  To evaluate vitamin D status in patients with basal cell nevus syndrome (BCNS) who practice photoprotection because of their genetic predisposition to skin cancer and to determine risk factors for deficiency.

Design  Retrospective cohort study.

Setting  Academic medical centers.

Patients  Forty-one ambulatory patients with BCNS who participated in a 2-year chemoprevention clinical trial. Population-based controls (n = 360) were selected and matched by age, sex, Fitzpatrick skin type, and season/geography.

Main Outcome Measures  Levels of 25-hydroxyvitamin D (25[OH]D) and vitamin D deficiency (defined as a 25[OH]D level of ≤20 ng/mL).

Results  Twenty-three patients with BCNS (56%) were vitamin D deficient. Patients with BCNS had mean 25(OH)D levels below those of the general population (–3 ng/mL; P = .02) and were 3 times more likely to be vitamin D deficient (56% vs 18%; P < .001). Levels of 25(OH)D were lower in patients who were overweight (–3.0 ng/mL; P = .04) and who had blood collected in the winter compared with the summer (–7.1 ng/mL; P < .001).

Conclusion  Patients with BCNS may be at increased risk for vitamin D deficiency, depending on their adherence to photoprotection practices.

Trial Registration  clinicaltrials.gov Identifier: NCT00023621

 
 
 
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