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Articles by A Lu
Total Records ( 2 ) for A Lu
  A Lu , L Wang and X. Zhang

Objective: To study the association of haplotypes of IL-8 -251T/A and 781 C/T single nucleotide polymorphisms (SNPs) with the susceptibility of respiratory syncytial virus (RSV).

Methods: This study included 101 hospitalized patients under 2 years who suffered from RSV pneumonia and108 hospitalized patients under 2 years who suffered only from pneumonia without RSV infection. Genotypes of two SNP loci in all enrolled persons were defined by allele-specific polymerase chain reaction. The allele’s frequencies of SNPs were analyzed with case–control study, linkage of two loci and haplotypes composed by the two loci were also studied.

Results: (i) The frequency of IL-8 -251T in cases was dramatically high (OR = 2.08, p = 0.0002). (ii) Haplotype of TC was significantly high in cases (p = 0.01).

Conclusion: These findings support that haplotype of TC composed by IL-8 -251T and 781C is associated with the susceptibility of RSV.

  X Zhang , L Wang , A Lu and M. Zhang

Objective: To summarize the clinical characteristics of idiopathic pulmonary haemosiderosis (IPH) to explore the aetiopathogenesis, risk factors, diagnosis and experiences in therapy of IPH. Methods: The documents of 28 IPH cases, who were hospitalized in Children’s Hospital of Fudan University between February 1989 and June 2009 were reviewed. Results: (i) fifteen cases were males and 13 were females, and 88.5% of the cases had first onset under the age of 10 years; (ii) the triad occurred in 57.1% cases; (iii) radiographic features of IPH including diffuse alveolar-type infiltrates, ground glass attenuation, interstitial reticular and micronodular patterns; (iv) haemosiderin-laden macrophages were found in 60.7% of the cases;(v) the trend of positive correlation was found between the severity of ventilatory restrictive pattern and the disease courses (r = 0.229, p = 0.237); and (vi) glucocorticosteroids can control the symptoms. Conclusion: (i) the clinical presentations are not classical. If long-term anaemia exists without reason, this case must be considered; (ii) corticosteroid can control the symptom; and (iii) IPH may be associated with the imbalance of immune system.

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