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Articles by A Kumanogoh
Total Records ( 2 ) for A Kumanogoh
  L Zhu , T. J Stalker , K. P Fong , H Jiang , A Tran , I Crichton , E. K Lee , K. B Neeves , S. F Maloney , H Kikutani , A Kumanogoh , E Pure , S. L Diamond and L. F. Brass

Objective— In dyslipidemic states, platelets become hyperreactive, secreting molecules that promote atherosclerosis. We have shown that the semaphorin family member, sema4D (CD100), is expressed on the surface of platelets and proposed that its role includes promoting thrombus growth by binding to nearby platelets and endothelial cells, both of which express sema4D receptors. Here we tested the hypothesis that deleting sema4D will attenuate the adverse consequences of dyslipidemia on platelets and the vessel wall.

Methods and Results— Platelet function and atherosclerotic lesion formation were measured in LDLR(–/–) and sema4D(–/–)LDLR(–/–) mice after 6 months on a high-fat diet. All of the mice developed the dyslipidemia expected on this diet in the absence of functional LDL receptors. However, when compared to LDLR(–/–) mice, sema4D(–/–) LDLR(–/–) mice had reduced lipid deposition in the descending aorta, a 6-fold decrease in the frequency of arterial occlusion and a reduction to near wild-type levels in the accumulation of platelets after injury. These differences were retained ex vivo, with a marked decrease in platelet accumulation on collagen under flow and in platelet aggregation.

Conclusions— These results show that loss of sema4D expression reduces the platelet hyperactivity otherwise found in dyslipidemia, and confers protection against the development of atherosclerosis.

  A Kumanogoh and M. Ogata

Cytokines play vital roles in both innate and adaptive immunity, in which they regulate immune and inflammatory responses and maintain immunological homeostasis. In addition to the immune system, they also exert diverse functions in other cells. Cytokines have pleiotropic functions and thus the molecular identification of cytokines and their receptors has been fundamental for understanding their mechanisms of action in several physiological and pathological conditions. A number of Japanese scientists have made significant contributions to the identification of cytokines, their receptors and signalling pathways, and application of these novel observations to the clinic has made possible the development of novel therapies for various immune diseases and related disorders. Here we present an overview of cytokines and their receptors identified in recent years by Japanese researchers.

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