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Articles by A Fernandez
Total Records ( 5 ) for A Fernandez
  V Cholvi , A Fernandez , E Jimenez , P Manzano and M. Raynal
 

The paper proposes a simple protocol that ensures sequential consistency. The protocol assumes that the shared memory abstraction is supported by the local memories of nodes that can communicate only by exchanging messages through reliable channels. Unlike other sequential consistency protocols, the one proposed here does not rely on a strong synchronization mechanism, such as an atomic broadcast primitive or a central node managing a copy of every shared object. From a methodological point of view, the protocol is built incrementally starting from the very definition of sequential consistency. It has the noteworthy property that a process that issues a write operation never has to wait for other processes. Depending on the current local state, most read operations issued also have the same property.

  A Fernandez and J. Chen
 

Proteins rely on associations to improve packing quality and thus maintain structural integrity. This makes packing deficiency a likely determinant of dosage sensitivity, that is, of the fitness impact of concentration imbalances relative to the stoichiometry of the protein complexes. This hypothesis was validated by examining evolution-related dosage imbalances: Duplicates of genes encoding for deficiently packed proteins are less likely to be retained than genes coding for well-packed proteins. This selection pressure is apparent in unicellular organisms, but is mitigated in higher eukaryotes. In human, this effect reveals a capacitance toward dosage imbalance. This capacitance is not expected in organisms with larger population size, where evolutionary forces are more efficient at promoting adaptive functional innovation and purifying selection, thus curbing the concentration imbalance arising from gene duplication. By examining miRNA target dissimilarities within human gene families, we show that the capacitance is operative at a post-transcriptional regulatory level: The higher the packing deficiency of a protein, the more likely that its paralogs will be dissimilarly targeted by miRNA to mitigate dosage imbalance. For families with low capacitance, paralog sequence divergence and family size correlate tightly with packing deficiency, just like in unicellular eukaryotes. Thus, a major component of human tolerance toward dosage imbalances is rooted in the paralog-discriminating capacity of miRNA regulation. The results may clarify the evolutionary etiology of aggregation-related diseases, since aggregation is often promoted by overexpression (a dosage imbalance) and aggregation propensity is associated with extreme packing deficiency.

  D. C Lopez Sandoval , E Maranon , A Fernandez , J Gonzalez , J. M Gasol , I Lekunberri , M Varela , A Calvo Diaz , X. A. G Moran , X. A Alvarez Salgado and F. G. Figueiras
 

We studied the importance of dissolved primary production in a coastal, productive ecosystem in relation to phytoplankton biomass, community structure and productivity. The photosynthetic production of dissolved organic carbon (DOCp) and particulate organic carbon was determined in mesocosm experiments during four contrasting oceanographic periods in the Ría de Vigo (NW Iberian Peninsula). We also determined the size-fractionated chlorophyll a concentration and primary production, phytoplankton taxonomic composition and bacterial production. Phytoplankton biomass was dominated by the >20 µm size fraction (mostly diatoms), except in winter, when the 2–20 and <2 µm size fractions (flagellates and picophytoplankton) increased in importance. The percentage of extracellular release (PER) had an average value of 19% and was independent of oceanographic period, phytoplankton biomass and production, taxonomic composition and size structure. During phytoplankton blooms, PER increased significantly from 14% in the exponential growth phase to 23% in the senescent phase. Bacterial carbon demand and DOCp were uncoupled, suggesting that other processes in addition to photosynthate exudation contribute most of the labile carbon to fuel bacterial metabolism. Dissolved primary production remains an important process in coastal phytoplankton assemblages throughout the year, irrespective of size-structure and community composition, but attaining higher significance during the decaying phase of blooms.

  A Fernandez , J. A. B Saameno , A Pinto Meza , J. V Luciano , J Autonell , D Palao , L Salvador Carulla , J. G Campayo , J. M Haro , A Serrano and the DASMAP investigators
 

Background

The World Health Organization (WHO) has stated that the three leading causes of burden of disease in 2030 are projected to include HIV/AIDS, unipolar depression and ischaemic heart disease.

Aims

To estimate health-related quality of life (HRQoL) and quality-adjusted life-year (QALY) losses associated with mental disorders and chronic physical conditions in primary healthcare using data from the diagnosis and treatment of mental disorders in primary care (DASMAP) study, an epidemiological survey carried out with primary care patients in Catalonia (Spain).

Method

A cross-sectional survey of a representative sample of 3815 primary care patients. A preference-based measure of health was derived from the 12-item Short Form Health Survey (SF–12): the Short Form–6D (SF–6D) multi-attribute health-status classification. Each profile generated by this questionnaire has a utility (or weight) assigned. We used non-parametric quantile regressions to model the association between both mental disorders and chronic physical condition and SF–6D scores.

Results

Conditions associated with SF–6D were: mood disorders, β = –0.20 (95% CI –0.18 to –0.21); pain, β = –0.08 (95%CI –0.06 to –0.09) and anxiety, β = –0.04 (95% CI –0.03 to –0.06). The top three causes of QALY losses annually per 100 000 participants were pain (5064), mood disorders (2634) and anxiety (805).

Conclusions

Estimation of QALY losses showed that mood disorders ranked second behind pain-related chronic medical conditions.

 
 
 
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