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Articles by A Ahmed
Total Records ( 2 ) for A Ahmed
  A Ahmed , H Khurana , V Gogia , S Mishra and S. Bhatnagar

According to World Health Organization (WHO), cancer pain can be controlled effectively with oral morphine in up to 90% of patients. Due to advancement in anticancer therapy and early presentation of cancer patients, the likelihood of cure is on an increasing trend. Awareness and education in the use of oral morphine, and easier regulations in procurement of oral morphine for use in cancer pain has lead to prescription of oral morphine to more patients earlier in pain therapy. In many patients, resolution of disease occurs and it becomes necessary to withdraw morphine. Guidance for starting medications is fairly easily obtained, but it is difficult to find information about switching or discontinuing opioids. The initial decrease in dose is well tolerated by the patient but the last few steps of complete withdrawal are difficult. We present 2 cases where the sustained release oral morphine was used as a bridge to withdraw immediate release oral morphine successfully in 2 patients after resolution of disease.

  A Ahmed , T Fujisawa , X. L Niu , S Ahmad , B Al Ani , K Chudasama , A Abbas , R Potluri , V Bhandari , C. M Findley , G. K.W Lam , J Huang , P. W Hewett , M Cudmore and C. D. Kontos

Atherosclerosis is promoted by a combination of hypercholesterolemia and vascular inflammation. The function of Angiopoietin (Ang)-2, a key regulator of angiogenesis, in the maintenance of large vessels is unknown. A single systemic administration of Ang-2 adenovirus (AdAng-2) to apoE–/– mice fed a Western diet significantly reduced atherosclerotic lesion size (40%) and oxidized LDL and macrophage content of the plaques. These beneficial effects were abolished by the inhibition of nitric oxide synthase (NOS). In endothelial cells, endothelial NOS activation per se inhibited LDL oxidation and Ang-2 stimulated NO release in a Tie2-dependent manner to decrease LDL oxidation. These findings demonstrate a novel atheroprotective role for Ang-2 when endothelial cell function is compromised and suggest that growth factors, which stimulate NO release without inducing inflammation, could offer atheroprotection.

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